Occupational Exposures to Organic Solvents and Asthma Symptoms in the Constances Cohort
Bibliographic Data
| ID | 15466697 |
|---|---|
| Authors | Guillaume Sit (0000-0003-0724-6057, Université Paris-Sud), Noémie Letellier (0000-0002-6925-1217, Scripps Institution of Oceanography), Yuriko Iwatsubo (Santé Publique France), Marcel Goldberg (0000-0002-6161-5880, Inserm), Bénédicte Leynaert (Université Paris-Sud), Rachel Nadif (0000-0003-4938-9339, Université Paris-Sud), Céline Ribet (0000-0003-2174-1126, Inserm), Nicolas Roche (0000-0002-3162-5033, Université Paris-Sud), Yves Roquelaure (0000-0001-6918-0909, Inserm), Raphaelle Varraso (0000-0002-3338-7825, Université Paris-Sud), Marie Zins (0000-0002-4540-4282, Inserm), Alexis Descatha (0000-0001-6028-3186, Université Paris-Sud), Nicole Le Moual (0000-0002-2723-5569, Université Paris-Sud, corresponding author), Orianne Dumas (0000-0001-8423-2826, Université Paris-Sud) |
| Year | 2021 |
| Volume | 18 |
| Issue | 17 |
| Pages | 9258-9258 |
| Publication date | 2021-09-02 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph18179258 |
| PMID | 34501848 |
| OpenAlex | W3196727936 |
| Language | EN |
| Citations received | 3 |
| References cited | 1 |
Solvents are used in many workplaces and may be airway irritants but few studies have examined their association with asthma. We studied this question in CONSTANCES (cohort of 'CONSulTANts des Centres d'Examens de Santé'), a large French cohort. Current asthma and asthma symptom scores were defined by participant-reported respiratory symptoms, asthma medication or attacks, and the sum of 5 symptoms, in the past 12 months, respectively. Lifetime exposures to 5 organic solvents, paints and inks were assessed by questionnaire and a population-based Job-Exposure Matrix (JEM). Cross-sectional associations between exposures and outcomes were evaluated by gender using logistic and negative binomial regressions adjusted for age, smoking habits and body mass index. Analyses included 115,757 adults (54% women, mean age 47 years, 9% current asthma). Self-reported exposure to ≥1 solvent was significantly associated with current asthma in men and women, whereas using the JEM, a significant association was observed only in women. Significant associations between exposures to ≥1 solvent and asthma symptom score were observed for both self-report (mean score ratio, 95%CI, women: 1.36, 1.31-1.42; men: 1.34, 1.30-1.40) and JEM (women: 1.10, 1.07-1.15; men: 1.14, 1.09-1.18). Exposure to specific solvents was significantly associated with higher asthma symptom score. Occupational exposure to solvents should be systematically sought when caring for asthma
Asthma · Cohort · Cohort study · Environmental health · Occupational asthma · Occupational exposure · Occupational safety and health · Pathology · Air Quality and Health Impacts · Indoor Air Quality and Microbial Exposure · Medicine · Occupational exposure and asthma · Internal Medicine
| Unique citing works | 3 |
|---|---|
| Citations per year | 0,75 |
| Citation span | 2022 - 2026 (5) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 3 |