The Prevalence of Anticitrullinated Protein Antibodies in Older Poles—Results from a Population-Based PolSenior Study
Bibliographic Data
| ID | 15466786 |
|---|---|
| Authors | Anna Chudek (0000-0002-6140-4602, Medical University of Silesia, corresponding author), Przemysław Kotyla (0000-0001-8376-6527, Medical University of Silesia), Małgorzata Mossakowska (0000-0002-9340-3188, International Institute of Molecular and Cell Biology), Tomasz Grodzicki (0000-0001-7819-2127, Jagiellonian University), Tomasz Zdrojewski (0000-0001-6015-8561, Gdańsk Medical University), Magdalena Olszanecka‐Glinianowicz (0000-0001-5632-5590, Medical University of Silesia), Jerzy Chudek (0000-0002-6367-7794, Medical University of Silesia), Aleksander Owczarek (0000-0003-1179-6932, Medical University of Silesia) |
| Year | 2022 |
| Volume | 19 |
| Issue | 21 |
| Pages | 14216-14216 |
| Publication date | 2022-10-31 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph192114216 |
| PMID | 36361095 |
| OpenAlex | W4307989853 |
| Language | EN |
| References cited | 42 |
Little is known about the occurrence of antibodies in older subjects. We analyzed the prevalence of anticitrullinated protein antibodies (anti-CCP) in a representative cohort of Polish older adults, participants of PolSenior substudy. Randomly selected 1537 serum samples of community-dwelling participants aged 65 and over. Questionnaires were completed by qualified interviewers and laboratory assessments served as a database for this analysis. The frequency of anti-CCP seropositivity (N = 50) was estimated at 3.25% (95% CI: 2.45-4.30%), being higher among women-4.05% (2.83-5.73%) than men-2.41% (1.48-3.86%). The frequency of anti-CCP seropositivity was decreasing with age from 4.29% in aged 65-74 years and 4.07% in 70-84 years to 1.50% in aged 85 years or above ( p 10 mg/dL or interleukin-6 ≥10 pg/mL), and female gender were associated with increased, while age ≥85 years with decreased risk of seropositivity. Multivariable logistic regression revealed that hypoalbuminemia, inflammatory status, and age ≥85 years were independently associated factors of anti-CCP seropositivity. The decreased frequency of anti-CCP seropositivity in the oldest old suggests shorter survival of the seropositive individuals who developed rheumatoid arthritis. It seems that low symptomatic RA remains frequently undiagnosed in older subjects
Antibody · Biology · Environmental health · Population · Medicine · Rheumatoid Arthritis Research and Therapies · Systemic Lupus Erythematosus Research · Systemic Sclerosis and Related Diseases · Immunology
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| Citation velocity | historical |
|---|---|
| Highly cited | No |