Early-Life Exposure to Organic Chemical Pollutants as Assessed in Primary Teeth and Cardiometabolic Risk in Mexican American Children

A Pilot Study

Bibliographic Data

ID15467767
AuthorsVidya S Farook (The University of Texas Rio Grande Valley), Feroz Akhtar (0009-0009-1381-3856, Texas A&M University – San Antonio, corresponding author), Rector Arya (0000-0001-7372-5043, Texas A&M University – San Antonio), Alice Yau (0000-0002-7681-3863, Southwest Research Institute), Srinivas Mummidi (0000-0002-4068-6380, Texas A&M University – San Antonio), Juan Carlos López-Alvarenga (0000-0002-0966-8766, The University of Texas Rio Grande Valley), Álvaro Díaz-Badillo (0000-0001-6267-3591, Texas A&M University – San Antonio), Roy G Resendez (Texas A&M University – San Antonio), Roy Resendez (Texas A&M University – San Antonio), Sharon P Fowler (0000-0003-1117-683X, The University of Texas at San Antonio Health Science Center), Hemant Kulkarni (0000-0001-6950-3341, Texas A&M University – San Antonio), Vijay Golla (0000-0002-2163-303X, Texas A&M University), Mahua Choudhury (Texas A&M University), Jane Lynch (0000-0003-2863-8594, The University of Texas at San Antonio Health Science Center), Jane L Lynch (The University of Texas at San Antonio Health Science Center), Donna M Lehman (0000-0001-8547-9927, Texas A&M University – San Antonio), Daniel E Hale (0000-0002-6415-926X, Penn State Milton S. Hershey Medical Center), Ralph A DeFronzo (0000-0003-3839-1724, The University of Texas at San Antonio Health Science Center), John Blangero (0000-0001-6250-5723, The University of Texas Rio Grande Valley), David Camann (Southwest Research Institute), David E Camann (Southwest Research Institute, San Antonio, TX 78238, USA), Ravindranath Duggirala (0000-0003-4761-597X, Texas A&M University – San Antonio), Suman Challa (The University of Texas at San Antonio Health Science Center), Suman N Challa (The University of Texas at San Antonio Health Science Center)
Year2025
Volume22
Issue10
Pages1494-1494
Publication date2025-09-27
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph22101494
PMID41154898
OpenAlexW4414612340
LanguageEN
References cited107

Early-life exposure to organic chemicals (OCs) may influence childhood obesity and associated cardiometabolic risk. These conditions have been shown to disproportionately affect minority populations such as Mexican Americans (MAs). However, information on the impact of organic chemicals on cardiometabolic risk in MA children is limited. Therefore, we conducted a pilot study to assess the extent to which exposure to organic chemicals influences cardiometabolic traits (CMTs) in MA children. We recalled 25 children from a previous study and collected 25 primary teeth from them. Chemical analyses of the teeth were performed using established protocols. Target analytes included acetaminophen (APAP); 3,5,6-trichloro-2-pyridinol (TCPy), 2-isopropyl-6-methyl-4-pyrimidinol (IMPy), diethyl phosphate (DEP), N,N-diethyl-m-toluamide (DEET), tris(2-butoxyethyl) phosphate (TBOEP), monoethyl phthalate (MEP), mono-n-butyl phthalate (MnBP), monoisobutyl phthalate (MiBP), monobenzyl phthalate (MBzP), mono-2-ethylhexyl phthalate (MEHP), mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), and mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP). The organic chemicals most frequently detected in the teeth were APAP; the insect repellent DEET; plasticizers MnBP and MiBP; and the plasticizer-derived metabolite MEHP. These five analytes were included in association analyses with selected CMTs. After adjusting for covariate (age, sex, tooth-type) effects, we found significant ( p p = 0.009) and positive association with triglycerides ( p < 0.10). These findings suggest a potential role for early-life exposures to organic chemicals in influencing cardiometabolic risk in MA children

Dibutyl phthalate · Diethyl phthalate · National Health and Nutrition Examination Survey · Phthalate · Pollutant · Primary metabolite · Birth, Development, and Health · Child Nutrition and Water Access · Health, Environment, Cognitive Aging

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