Visceral Fat Is a Negative Determinant of Bone Health in Obese Postmenopausal Women
Bibliographic Data
| ID | 15467807 |
|---|---|
| Authors | Deepti Sharma (0000-0002-9850-1713, University of South Australia), Paul Anderson (0000-0002-8156-5542, University of South Australia, corresponding author), Howard A Morris (0000-0002-2745-3750, University of South Australia), Howard Morris (Clinical and Health Sciences Academic Unit, University of South Australia, Adelaide 5001, Australia), Peter M Clifton (0000-0002-6411-626X, University of South Australia) |
| Year | 2020 |
| Volume | 17 |
| Issue | 11 |
| Pages | 3996-3996 |
| Publication date | 2020-06-04 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph17113996 |
| PMID | 32512872 |
| OpenAlex | W3033422051 |
| Language | EN |
| References cited | 47 |
The protective effect of obesity on bone health has been challenged by studies that link visceral adiposity to poor bone microarchitecture in young obese men and women. In postmenopausal women, the role of visceral adipose tissue (VAT) on bone turnover markers (BTMs) has not been investigated. The aim was to investigate the impact of VAT on BTMs, total bone mineral density (BMD), vitamin D metabolites and parathyroid levels (1-84 PTH) levels in postmenopausal women. A total of 76 lean and overweight women (without osteoporosis) underwent VAT measurements by dual-energy X-ray absorptiometry (iDXA). Blood samples were analyzed for serum C-terminal telopeptide of type 1 collagen (CTX-1), osteocalcin, bone-specific alkaline phosphatase (bone ALP), 1-84 PTH and vitamin D (25 hydroxyvitamin D, 25(OH)D) levels. VAT volumes ranged from 91 to 3392 cm 3 and body mass index (BMI) ranged from 18.3 to 53.9 kg/m 2 . Women in the highest VAT quartile had significantly lower CTX-1, 25(OH)D, osteocalcin and the highest BMD ( p p p p < 0.05). Among all measures of adiposity, VAT was the strongest independent determinant of BMD and BTMs. In clinical settings, VAT, and not BMI, may be a sensitive predictor of bone health in obese women
Adipose tissue · Alkaline phosphatase · Body mass index · Bone density · Bone mineral · Bone remodeling · N-terminal telopeptide · Obesity · Osteocalcin · Osteoporosis · Overweight · Vitamin D and neurology · Bone health and osteoporosis research · Bone health and treatments · Chemistry · Medicine · Vitamin D Research Studies · Endocrinology · Internal Medicine
| Highly cited | No |
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