Effect of Naturally Occurring Ozone Air Pollution Episodes on Pulmonary Oxidative Stress and Inflammation
Bibliographic Data
| ID | 15467834 |
|---|---|
| Authors | C S Pirozzi (0000-0002-1533-1916, University of Utah, corresponding author), Cheryl Pirozzi (University of Utah), Anne Sturrock (University of Utah), Hsin-Yi Weng (University of Utah), Hsin‐yi Weng (0000-0001-5514-099X, University of Utah), Tom Greene (0000-0002-3706-7570, University of Utah), Mary Beth Scholand (0000-0001-6513-8893, University of Utah), Mary Scholand (University of Utah), Richard E Kanner (0000-0001-6915-599X, University of Utah), Richard Kanner (University of Utah), Robert III (University of Utah) |
| Year | 2015 |
| Volume | 12 |
| Issue | 5 |
| Pages | 5061-5075 |
| Publication date | 2015-05-12 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph120505061 |
| PMID | 25985308 |
| PMCID | PMC4454954 |
| OpenAlex | W2141839080 |
| Language | EN |
| Citations received | 2 |
| References cited | 33 |
This study aimed to determine if naturally occurring episodes of ozone air pollution in the Salt Lake Valley in Utah, USA, during the summer are associated with increased pulmonary inflammation and oxidative stress, increased respiratory symptoms, and decreased lung function in individuals with chronic obstructive pulmonary disease (COPD) compared to controls. We measured biomarkers (nitrite/nitrate (NOx), 8-isoprostane) in exhaled breath condensate (EBC), spirometry, and respiratory symptoms in 11 former smokers with moderate-to-severe COPD and nine former smokers without airflow obstruction during periods of low and high ozone air pollution. High ozone levels were associated with increased NOx in EBC in both COPD (8.7 (±8.5) vs. 28.6 (±17.6) μmol/L on clean air vs. pollution days, respectively, p < 0.01) and control participants (7.6 (±16.5) vs. 28.5 (±15.6) μmol/L on clean air vs. pollution days, respectively, p = 0.02). There was no difference in pollution effect between COPD and control groups, and no difference in EBC 8-isoprostane, pulmonary function, or respiratory symptoms between clean air and pollution days in either group. Former smokers both with and without airflow obstruction developed airway oxidative stress and inflammation in association with ozone air pollution episodes
Air pollution · Asthma · COPD · Exhaled breath condensate · Oxidative stress · Ozone · Pulmonary function testing · Respiratory system · Spirometry · Air Quality and Health Impacts · Chemistry · Chronic Obstructive Pulmonary Disease (COPD) Research · Climate Change and Health Impacts · Medicine · Environmental Chemistry · Internal Medicine
| Citations per year | 0.4 |
|---|---|
| Citation span | 2021 - 2026 (6) |
| Highly cited | No |