Poor Sleep Quality Is Associated with Higher Hemoglobin A1c in Pregnant Women

A Pilot Observational Study

Bibliographic Data

ID15467933
AuthorsSanika Chirwa (Meharry Medical College, corresponding author), Chioma R Nwabuisi (Meharry Medical College), Gwinnett Ladson (Meharry Medical College), Gwinnett M Ladson (Obstetrics and Gynecology, Meharry Medical College, 1005 Dr. D.B. Todd Jr. Boulevard, Nashville, TN 37208, USA), Linda Korley (Meharry Medical College), Janice E Whitty (Meharry Medical College), Robin Atkinson (Meharry Medical College), John T Clark (Meharry Medical College)
Year2018
Volume15
Issue10
Pages2287-2287
Publication date2018-10-18
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph15102287
PMID30340366
OpenAlexW2897604532
LanguageEN
Citations received3
References cited50

We hypothesized that poor sleep quality exacerbates glucose intolerance manifested as elevated glycosylated hemoglobin (HbA1c), which increases the risk for gestational diabetes. To test this, 38 pregnant and 22 non-pregnant (age, 18−35 years; body-mass index, 20−35 kg/m2) otherwise healthy women were enrolled in the study. Sleep quality was assessed during gestational week 24 (pregnant), or outside of the menstrual period (non-pregnant), using qualitative (Pittsburgh Sleep Quality Index) and objective (actigraphic wrist-watch) measures. Blood glucose, total cortisol, and depression status were evaluated. Eight pregnant and one non-pregnant women were lost to follow-up, or withdrew from the study. There was a higher incidence of poor sleep quality in pregnant (73%) relative to non-pregnant women (43%). Although actigraphic data revealed no differences in actual sleep hours between pregnant and non-pregnant women, the number of wake episodes and sleep fragmentation were higher in pregnant women. Poor sleep quality was positively correlated with higher HbA1c in both pregnant ( r = 0.46, n = 26, p = 0.0151) and non-pregnant women ( r = 0.50, n = 19, p = 0.0217), reflecting higher average blood glucose concentrations. In contrast, poor sleep was negatively correlated with cortisol responses in pregnant women ( r = -0.46, n = 25, p = 0.0167). Three pregnant women had elevated one-hour oral glucose tolerance test results (>153 mg/dL glucose). These same pregnant women exhibited poor sleep quality. These results support the suggestion that poor sleep quality is an important risk factor that is associated with glucose intolerance and attendant health complications in pregnancy

Body mass index · Gestation · Gestational diabetes · Insomnia · Obstetrics · Pittsburgh Sleep Quality Index · Pregnancy · Psychiatry · Sleep quality · Birth, Development, and Health · Gestational Diabetes Research and Management · Medicine · Sleep and related disorders · Internal Medicine

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