Association of Hand Grip Strength with Mild Cognitive Impairment in Middle-Aged and Older People in Guangzhou Biobank Cohort Study

Bibliographic Data

ID15468394
AuthorsYali Jin (Twelfth Guangzhou City People's Hospital), Ya-Li Jin (Guangzhou Twelfth People’s Hospital, Guangzhou 510620, China), Lin Xu (0000-0002-4074-3883, Sun Yat-sen University), Chaoqiang Jiang (Twelfth Guangzhou City People's Hospital, corresponding author), Chao-Qiang Jiang (Guangzhou Twelfth People’s Hospital, Guangzhou 510620, China), Weisen Zhang (Twelfth Guangzhou City People's Hospital), Wei-Sen Zhang (Guangzhou Twelfth People’s Hospital, Guangzhou 510620, China), Jing Pan (0000-0002-1360-1636, Twelfth Guangzhou City People's Hospital), Feng Zhu (0000-0003-3663-6046, Twelfth Guangzhou City People's Hospital), Tong Zhu (0000-0001-5704-4264, Twelfth Guangzhou City People's Hospital), G Neil Thomas (0000-0002-2777-1847, University of Birmingham), Th Lam (0000-0002-2033-9971, University of Hong Kong)
Year2022
Volume19
Issue11
Pages6464-6464
Publication date2022-05-26
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph19116464
PMID35682049
OpenAlexW4281553932
LanguageEN
References cited53

Background: Lower hand grip strength has been linked to cognitive impairment, but studies in older Chinese are limited. We examined the association of hand grip strength with cognitive function in a large sample of older Chinese. Methods: 6806 participants aged 50+ years from the Guangzhou Biobank Cohort Study (GBCS) were included. Relative grip strength was calculated by absolute handgrip strength divided by the body mass index (BMI). Cognitive function was assessed using the Delayed Word Recall Test (DWRT, from 0 to 10) and the Mini Mental State Examination (MMSE, from 0 to 30), with higher scores indicating better cognition. Results: After adjusting for multiple potential confounders, lower absolute grip strength and relative grip strength were significantly associated with lower DWRT (all p < 0.05) in all participants. No significant interaction effects between sex and handgrip strength on cognitive impairment were found (p from 0.27 to 0.87). No significant association between handgrip strength and total MMSE scores was found in the total sample or by sex (p from 0.06 to 0.50). Regarding the individual components of MMSE, lower absolute and relative grip strength were significantly associated with lower scores of the recall memory performance in all participants (p from 0.003 to 0.04). Conclusion: We have shown for the first time a positive association of grip strength with recall memory performance, but not general cognitive function in older people, which warrants further investigation

Association (psychology · Body mass index · Cognition · Cognitive impairment · Cohort · Cohort study · Confounding · Effects of sleep deprivation on cognitive performance · Grip strength · Hand strength · Mini–Mental State Examination · Physical medicine and rehabilitation · Physical therapy · Psychiatry · Diet and metabolism studies · Medicine · Nutrition and Health in Aging · Nutritional Studies and Diet · Psychology · Gerontology · Internal Medicine

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