Oestrogenic Activity in Girls with Signs of Precocious Puberty as Exposure Biomarker to Endocrine Disrupting Chemicals
A Pilot Study
Bibliographic Data
| ID | 15468680 |
|---|---|
| Authors | Marta Gea (0000-0002-4963-048X, University of Turin, corresponding author), Anna Toso (0000-0003-3028-2304, Inserm), Giuseppe Nicolò Bentivegna (0000-0002-6967-7971, University of Turin), Raffaele Buganza (0000-0003-1850-2300, Ospedale Regina Margherita), Enrica Abrigo (0000-0002-4334-9822, Ospedale Regina Margherita), Luisa De Sanctis (0000-0003-2113-6196, Ospedale Regina Margherita), Tiziana Schilirò (0000-0002-0813-3524, University of Turin) |
| Year | 2022 |
| Volume | 20 |
| Issue | 1 |
| Pages | 14-14 |
| Publication date | 2022-12-20 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph20010014 |
| PMID | 36612336 |
| OpenAlex | W4311963462 |
| Language | EN |
| References cited | 75 |
The relationship between endocrine disrupting chemical (EDC) exposure and Precocious Puberty (PP) was investigated in this pilot study, involving girls with signs of PP (P) and pre-pubertal girls (C). Risk factors for PP were assessed through questionnaires, while 17β-oestradiol (E2) levels and oestrogenic activity were quantified on sera. The oestrogenic activity, expressed as E2 equivalent concentration (EEQ), was applied as EDC exposure biomarker. Questionnaires showed a low EDC knowledge, a high EDC exposure, and a potential relationship between some habits at risk for EDC exposure and PP. EEQs were similar between C and P; however, they were significantly higher in girls living in an urban environment than in girls living in a rural environment, suggesting a potential higher EDC exposure in cities. The results of this pilot study highlighted the need to raise awareness on EDCs and can be considered a starting point to clarify the relationship between EDC exposure and PP
Biology · Biomarker · Endocrine system · Environmental health · Exposure assessment · Hormone · Precocious puberty · Effects and risks of endocrine disrupting chemicals · Estrogen and related hormone effects · Hypothalamic control of reproductive hormones · Medicine · Internal Medicine · Physiology · Toxicology
| Highly cited | No |
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