Moderators and Other Predictors of Methylphenidate Response in Children and Adolescents with ADHD
Bibliographic Data
| ID | 15468740 |
|---|---|
| Authors | Barbara D’Aiello (0000-0003-1226-329X, Libera Università Maria SS. Assunta), Silvia Di Vara (0000-0001-8880-5644, Bambino Gesù Children's Hospital), Pietro De Rossi (0000-0001-5344-7525, Bambino Gesù Children's Hospital), Italo Pretelli (Bambino Gesù Children's Hospital), Stefano Vicari (0000-0001-7667-5811, Università Cattolica del Sacro Cuore), Deny Menghini (0000-0002-3459-2601, Bambino Gesù Children's Hospital, corresponding author) |
| Year | 2022 |
| Volume | 19 |
| Issue | 3 |
| Pages | 1640-1640 |
| Publication date | 2022-01-31 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph19031640 |
| PMID | 35162663 |
| OpenAlex | W4210657406 |
| Language | EN |
| References cited | 46 |
Methylphenidate (MPH) is the treatment of first choice for developmental ADHD. To date, no reliable method to predict how patients will respond to MPH exists and conflicting results are reported on clinical characteristics of responders. The present study aims to give a more precise characterization of the patients who will respond best to MPH to help clinicians in defining the treatment plan. Age, neuropsychological functioning (i.e., attention and working memory), and behavioral/emotional symptoms of 48 drug-naïve children and adolescents with ADHD (42 boys and 6 girls, age-range 6-16 years, mean age 10.5 ± 2.5 years, mean IQ 101.3 ± 11.2) were studied to assess how these different characteristics affected a single-dose MPH response. Four hierarchical linear regression models were used to explore whether age, neuropsychological measures at baseline, and behavioral/emotional symptoms could predict attention and working memory measures after a single-dose MPH administration. We found that improvement in attention and working memory was predicted by age, neuropsychological measures at baseline, and severity of ADHD symptoms. No behavioral and emotional symptoms predicted single-dose MPH response with the exception of conduct symptoms
Cognition · Methylphenidate · Multilevel model · Neuropsychology · Psychiatry · Working memory · Attention Deficit Hyperactivity Disorder · Clinical Psychology · Medicine · Neural and Behavioral Psychology Studies · Psychology
Attention-deficit/hyperactivity disorder
The Revised Conners' Parent Rating Scale (CPRS-R)
Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults
Age differences in short-term retention of rapidly changing information.
The Unity and Diversity of Executive Functions and Their Contributions to Complex “Frontal Lobe” Tasks
| Highly cited | No |
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