The Development of Keratopathy after Surgery-Indicated Chronic Rhinosinusitis

A Population-Based Cohort Study

Bibliographic Data

ID15469264
AuthorsHung-Jui Hsu (Chang Bing Show Chwan Memorial Hospital), Chia‐Yi Lee (0000-0002-5719-0488, Chung Hwa University of Medical Technology), Kun‐Lin Yang (0000-0002-8968-0844, Kaohsiung Chang Gung Memorial Hospital), Kun-Lin Yang (Department of Otolaryngology–Head and Neck Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan), Hung‐Chi Chen (0000-0002-1117-7878, Chang Gung University), Chi‐Chin Sun (0000-0001-9466-6986, Chang Gung University), Chi-Chin Sun (Department of Ophthalmology, Chang Gung Memorial Hospital, Keelung 204, Taiwan), Jing‐Yang Huang (0000-0002-0794-9388, Chung Shan Medical University Hospital), Hung‐Yu Lin (0000-0002-6647-7069, Chung Chou University of Science and Technology), Shun‐Fa Yang (0000-0002-0365-7927, Chung Shan Medical University Hospital, corresponding author)
Year2019
Volume16
Issue7
Pages1218-1218
Publication date2019-04-05
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph16071218
PMID30959733
OpenAlexW2926048625
LanguageEN
Citations received1
References cited28

The aim of the present study was to evaluate the risk of developing keratopathy in patients with surgery-indicated chronic rhinosinusitis (CRS) via the National Health Insurance Research Database in Taiwan. Patients with a diagnostic code of CRS and who received functional endoscopic sinus surgery (FESS) were considered to have surgery-indicated CRS. The exclusion criteria were legal blindness, an ocular tumor, eyeball removal or previous keratopathy, and each individual in the study group was matched to four non-CRS patients by age and sex. The outcome was set as the occurrence of keratopathy according to the diagnostic codes after the index date. Cox proportional hazard regression was used for statistical analysis. A total of 6053 patients with surgery-indicated CRS and another 24,212 non-CRS individuals were enrolled after exclusions. The age and sex distributions were identical between the two groups due to matching, while comorbidities, including hypertension, diabetes mellitus, and other cardiovascular disorders, were significantly higher in the study group. There were 231 episodes of keratopathy in the study group, and 695 episodes of keratopathy in the control group after the index date, for which study group showed a significantly higher rate of developing keratopathy with an adjusted hazard ratio of 1.208 and a higher cumulative probability. In subgroup analysis, female sex with surgery-indicated CRS showed a significantly greater risk of developing keratopathy. In conclusion, surgery-indicated CRS that needs FESS to relieve symptoms is a potential risk factor for keratopathy

Chronic rhinosinusitis · Cohort · Confidence interval · Diabetes mellitus · Functional endoscopic sinus surgery · Hazard ratio · Proportional hazards model · Sinusitis · Medicine · Nasal Surgery and Airway Studies · Ocular Surface and Contact Lens · Sinusitis and nasal conditions · Internal Medicine · Surgery

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