A Longitudinal Study of the Relationship between Shift Work and Prostate-Specific Antigen in Healthy Male Workers
Bibliographic Data
| ID | 15469512 |
|---|---|
| Authors | Yesung Lee (0000-0002-8844-492X, Kangbuk Samsung Hospital), Won–Cheol Lee (0000-0001-8535-3988, Kangbuk Samsung Hospital), Hyoung‐Ryoul Kim (0000-0001-7535-3140, The Catholic University of Korea Seoul St. Mary's Hospital, corresponding author), Hyoung-Ryoul Kim (Department of Occupational and Environmental Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea) |
| Year | 2021 |
| Volume | 18 |
| Issue | 14 |
| Pages | 7458-7458 |
| Publication date | 2021-07-13 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph18147458 |
| PMID | 34299909 |
| OpenAlex | W3178085112 |
| Language | EN |
| References cited | 41 |
As shift work has become prevalent globally, it is important to evaluate the health effects of shift work on employees. Several studies have demonstrated a positive association between shift work and prostate cancer. Therefore, we aimed to further examine the relationship between shift work and elevated prostate-specific antigen (PSA). Our study collected data from 66,817 male participants at baseline and followed up for about 6 years. We categorized shift worker status and shift schedule types. To evaluate the risk of elevated PSA on shift workers, we estimated hazard ratios using the Cox proportional hazards regression analyses. During a median follow-up of 4.1 years, 1030 participants developed elevated PSA. The multivariable-adjusted hazard ratio (HR) of elevated PSA for shift workers compared with daytime workers was 1.37 (1.04-1.80). Among shift workers, rotating shift workers (HR = 1.47, 95% CI 1.06-2.03) showed a significantly increased risk of elevated PSA compared with daytime workers. Our longitudinal study provides evidence for an association between shift work, especially rotating shift work, and elevations of PSA
Cancer · Confidence interval · Hazard ratio · Longitudinal study · Pathology · Proportional hazards model · Prostate cancer · Prostate-specific antigen · Shift work · Work shift · Advanced Glycation End Products research · Air Quality and Health Impacts · Medicine · Sleep and Work-Related Fatigue · Internal Medicine
| Highly cited | No |
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