First- and Third-Trimester Urinary Phthalate Metabolites in the Development of Hypertensive Diseases of Pregnancy

Bibliographic Data

ID15469581
AuthorsSabrina Bedell (0000-0003-0267-2209, University of Minnesota), Grace R Lyden (0000-0003-1408-851X, University of Minnesota), Sheela Sathyanarayana (0000-0002-1480-0397, University of Washington), Emily S Barrett (0000-0001-9463-524X, Rutgers, the State University of New Jersey), Kelly K Ferguson (0000-0001-8467-3250, National Institute of Environmental Health Sciences), Ashley R Santilli (0000-0001-5708-7109, Mayo Clinic), Ashley Santilli (Mayo Clinic), Newell Richard Bush (0000-0003-0217-9975, University of California, San Francisco), Shanna H Swan (0000-0001-9564-0614, Icahn School of Medicine at Mount Sinai), Thomas F McElrath (0000-0003-0857-0107, Brigham and Women's Hospital), Ruby H N Nguyen (0000-0002-6598-8457, University of Minnesota, corresponding author)
Year2021
Volume18
Issue20
Pages10627-10627
Publication date2021-10-11
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph182010627
PMID34682373
OpenAlexW3206490573
LanguageEN
Citations received2
References cited35

The purpose of this study was to determine whether maternal urinary phthalate metabolite concentrations are associated with the development of higher blood pressure or pregnancy-induced hypertension (PIH). Participants were women without chronic hypertension who enrolled in The Infant Development and the Environment Study, a prospective pregnancy cohort conducted at four U.S. academic medical centers from 2010-2012. Prenatal records were reviewed to obtain blood pressure measurements and diagnoses of PIH (gestational hypertension, preeclampsia, eclampsia, and HELLP syndrome, defined as hemolysis, elevated liver enzymes, and low platelet count). Complete-case analyses used multivariable linear and logistic regression for analysis of blood pressure measurements and PIH diagnoses, respectively. In the final dataset (N = 668), higher concentrations of first-trimester monoethyl phthalate (MEP) and mono-3-carboxypropyl phthalate (MCPP) and third-trimester mono-isobutyl phthalate (MiBP) were significantly associated with a medical chart diagnosis of PIH. First-trimester mono-n-butyl phthalate (MBP) and MEP along with the sum of di-(2-ethylhexyl) phthalate metabolites (∑DEHP) were each associated with increased systolic blood pressure across pregnancy. In conclusion, several phthalate metabolite concentrations were significantly associated with PIH and greater increases in systolic blood pressure across pregnancy

Biology · Blood pressure · Gestational hypertension · Gynecology · Obstetrics · Phthalate · Preeclampsia · Pregnancy · Urinary system · Birth, Development, and Health · Chemistry · Effects and risks of endocrine disrupting chemicals · Health, Environment, Cognitive Aging · Medicine · Endocrinology · Internal Medicine · Physiology

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