S100B Maternal Blood Levels in Gestational Diabetes Mellitus Are Birthweight, Gender and Delivery Mode Dependent

Bibliographic Data

ID15469740
AuthorsLaura Abella (0000-0003-2188-248X, Hospital Universitario Dexeus), Ebe D’Adamo (University of Chieti-Pescara), Mariachiara Strozzi (0000-0001-8852-7445, Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo), Joan Sánchez-de-Toledo (0000-0002-9108-4750, Hospital Sant Joan de Déu Barcelona), M Pérez‐Cruz (0000-0002-5132-0050, Hospital Sant Joan de Déu Barcelona), Miriam Perez-Cruz (Fetal Medicine Research Center, Hospital Sant Joan de Deus, University of Barcelona, 08950 Barcelona, Spain), O Gómez (0000-0003-4183-9876, Hospital Sant Joan de Déu Barcelona), Ernesto Abella (Hospital Dr. Max Peralta Jimènez, Cartago 30101, Costa Rica), Maurizio Cassinari (Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo), Roberto Guaschino (Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo), Laura Mazzucco (0009-0002-4226-0954, Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo), Antonio Maconi (0000-0002-1904-7277, Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo), Stefania Testa (0000-0002-4067-8110, Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo), Cristian Zanelli (Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo), Marika Perrotta (University of Chieti-Pescara), Patacchiola Roberta (University of Chieti-Pescara), Costanza Neri (0009-0006-3262-9593, University of Chieti-Pescara), Neri Costanza Renata (Department of Pediatrics, G. d’Annunzio University, 65100 Chieti, Italy), Giorgia Gasparroni (0000-0001-9495-5577, University of Chieti-Pescara), Ester Vitacolonna (0000-0003-1756-661X, University of Chieti-Pescara), Francesco Chiarelli (0000-0002-3724-1495, University of Chieti-Pescara), Diego Gazzolo (0000-0002-0643-2555, University of Chieti-Pescara, corresponding author)
Year2022
Volume19
Issue3
Pages1028-1028
Publication date2022-01-18
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph19031028
PMID35162052
OpenAlexW4206148072
LanguageEN
References cited37

Gestational Diabetes Mellitus (GDM) is one of the main causes of perinatal mortality/morbidity. Today, a parameter offering useful information on fetal central nervous system (CNS) development/damage is eagerly awaited. We investigated the role of brain-protein S100B in the maternal blood of GDM pregnancies by means of a prospective case-control study in 646 pregnancies (GDM: n = 106; controls: n = 530). Maternal blood samples for S100B measurement were collected at four monitoring time-points from 24 weeks of gestation to term. Data was corrected for gender and delivery mode and correlated with gestational age and weight at birth. Results showed higher ( p p p < 0.01). The present findings show the usefulness of S100B in CNS to monitor high-risk pregnancies during perinatal standard-of-care procedures. The results suggest that further investigations into its potential role as an early marker of CNS growth/damage in GDM population are needed

Biology · Birth weight · Caesarean section · Diabetes mellitus · Fetus · Gestation · Gestational age · Gestational diabetes · Gynecology · Obstetrics · Population · Pregnancy · Gestational Diabetes Research and Management · Medicine · Neonatal and fetal brain pathology · Pregnancy-related medical research · Endocrinology

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