Exposure to Night-Time Traffic Noise, Melatonin-Regulating Gene Variants and Change in Glycemia in Adults

Bibliographic Data

ID15470241
AuthorsIkenna C Eze (0000-0001-9748-2162, Swiss Tropical and Public Health Institute, corresponding author), Medea Imboden (0000-0002-9414-5862, Swiss Tropical and Public Health Institute), María Foraster (0000-0003-4450-4123, Swiss Tropical and Public Health Institute), Emmanuel Schaffner (0000-0002-0309-4028, Swiss Tropical and Public Health Institute), Ashish Kumar (0000-0002-8280-1615, Swiss Tropical and Public Health Institute), Danielle Vienneau (0000-0002-6309-6439, Swiss Tropical and Public Health Institute), Harris Héritier (Swiss Tropical and Public Health Institute), Franziska Rudzik (University of Basel), Laurie Thiesse (0000-0002-1034-9674, University of Basel), Reto Pieren (0000-0001-5280-2230, Swiss Federal Laboratories for Materials Science and Technology), Arnold von Eckardstein (0000-0002-1666-2266, University Hospital of Zurich), Christian Schindler (0000-0003-3059-7613, Swiss Tropical and Public Health Institute), Mark Brink (0000-0003-0696-4401, Federal Office for the Environment), Jean Marc Wunderli (0000-0002-5956-8229, Swiss Federal Laboratories for Materials Science and Technology), Christian Cajochen (0000-0003-2699-7171, University of Basel), Martin Röösli (0000-0002-7475-1531, Swiss Tropical and Public Health Institute), Nicole Probst-Hensch (0000-0001-8561-5976, Swiss Tropical and Public Health Institute)
Year2017
Volume14
Issue12
Pages1492-1492
Publication date2017-12-01
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph14121492
PMID29194408
OpenAlexW2772139245
LanguageEN
Citations received2
References cited57

Traffic noise has been linked to diabetes, with limited understanding of its mechanisms. We hypothesize that night-time road traffic noise (RTN) may impair glucose homeostasis through circadian rhythm disturbances. We prospectively investigated the relationship between residential night-time RTN and subsequent eight-year change in glycosylated hemoglobin (ΔHbA1c) in 3350 participants of the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA), adjusting for diabetes risk factors and air pollution levels. Annual average RTN (Lnight) was assigned to participants in 2001 using validated Swiss noise models. HbA1c was measured in 2002 and 2011 using liquid chromatography. We applied mixed linear models to explore RTN-ΔHbA1c association and its modification by a genetic risk score of six common circadian-related MTNR1B variants (MGRS). A 10 dB difference in RTN was associated with a 0.02% (0.003-0.04%) increase in mean ΔHbA 1c in 2142 non-movers. RTN-ΔHbA1c association was modified by MGRS among diabetic participants ( P interaction = 0.001). A similar trend in non-diabetic participants was non-significant. Among the single variants, we observed strongest interactions with rs10830963, an acknowledged diabetes risk variant also implicated in melatonin profile dysregulation. Night-time RTN may impair glycemic control, especially in diabetic individuals, through circadian rhythm disturbances. Experimental sleep studies are needed to test whether noise control may help individuals to attain optimal glycemic levels

Biology · Melatonin · Noise (video · Circadian rhythm and melatonin · Computer Science · Medicine · Obesity, Physical Activity, Diet · Sleep and related disorders · Endocrinology · Internal Medicine

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