Secondhand Smoke Correlates with Elevated Neutrophil-Lymphocyte Ratio and Has a Synergistic Effect with Physical Inactivity on Increasing Susceptibility to Type 2 Diabetes Mellitus
A Community-Based Case Control Study
Bibliographic Data
| ID | 15470780 |
|---|---|
| Authors | Yohanes Andy Rias (0000-0001-5403-2161, Institut Ilmu Kesehatan Bhakti Wiyata), Christopher J Gordon (0000-0003-2698-4864, The University of Sydney), Shu‐Fen Niu (Taipei Medical University), Bayu Satria Wiratama (0000-0001-9965-778X, Universitas Gadjah Mada), Ching-Wen Chang (0000-0002-9132-3539, Taipei Medical University Hospital), Hsiu‐Ting Tsai (0000-0003-1137-9274, Taipei Medical University, corresponding author) |
| Year | 2020 |
| Volume | 17 |
| Issue | 16 |
| Pages | 5696-5696 |
| Publication date | 2020-08-06 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph17165696 |
| PMID | 32781787 |
| OpenAlex | W3046959220 |
| Language | EN |
| Citations received | 2 |
| References cited | 6 |
Secondhand smoke (SHS) and physical inactivity are thought to be associated with type 2 diabetes mellitus (T2DM), but the synergistic effect of SHS with physical inactivity and their relationships with T2DM-associated inflammation biomarkers have not been estimated. We investigated the roles of SHS exposure and physical inactivity and their synergistic effect on T2DM risk and their relationships with T2DM associated inflammation biomarkers, neutrophil-lymphocyte ratio (NLR) and white blood cells (WBCs). A case-control study was conducted in total 588 participants (294 case T2DM and 294 healthy controls) from five community clinics in Indonesia. Participants completed a standardized questionnaire on demographic information, smoking status, physical activity habits and food consumption. WBCs and NLR levels were determined using an automated hematology analyzer. Adjusted odds ratios (AORs) and 95% confidence intervals (CIs) were analyzed using multiple logistic regression model. The synergistic effect was analyzed using additive interaction for logistic regression. Physical inactive people exposed to SHS exhibited a synergistically increased 7.78-fold risk of T2DM compared with people who were not exposed to SHS and who were physically active. SHS is significantly correlated with a high NLR, WBCs and has a synergistic effect with physical inactivity on increasing susceptibility to T2DM
Case-control study · Confidence interval · Diabetes mellitus · Environmental health · Logistic regression · Lymphocyte · Neutrophil to lymphocyte ratio · Obesity · Odds ratio · Type 2 diabetes · Type 2 Diabetes Mellitus · Adipokines, Inflammation, and Metabolic Diseases · Adipose Tissue and Metabolism · Medicine · Smoking Behavior and Cessation · Endocrinology · Immunology · Internal Medicine
Minimum amount of physical activity for reduced mortality and extended life expectancy
Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045
Classification and Diagnosis of Diabetes
IDF Diabetes Atlas
Worldwide burden of disease from exposure to second-hand smoke
Global estimates of diabetes prevalence for 2013 and projections for 2035
| Citations per year | 0.4 |
|---|---|
| Citation span | 2021 - 2021 (1) |
| Highly cited | No |