The Pattern of Hemoglobin A1C Trajectories and Risk of Herpes Zoster Infection

A Follow-Up Study

Bibliographic Data

ID15470866
AuthorsBo‐Lin Pan (Kaohsiung Chang Gung Memorial Hospital), Bo-Lin Pan (Department of Family Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan), C James Chou (0000-0002-1791-3370, Kaohsiung Chang Gung Memorial Hospital), Chia-Pei Chou (Department of Family Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan), Kun-Siang Huang (0000-0001-6215-4724, Kaohsiung Chang Gung Memorial Hospital), Pin-Jie Bin (Kaohsiung Chang Gung Memorial Hospital), Kuei-Hau Luo (Kaohsiung Medical University), Kuei‐Hau Luo (Kaohsiung Medical University), Hung-Yi Chuang (0000-0002-8321-8720, Kaohsiung Medical University, corresponding author)
Year2022
Volume19
Issue5
Pages2646-2646
Publication date2022-02-24
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph19052646
PMID35270336
OpenAlexW4214535177
LanguageEN
References cited30

To investigate the risks of herpes zoster (HZ) infection among heterogeneous HbA1C trajectories of patients with newly diagnosed type 2 diabetes, this cohort study used data from the Chang Gung Research Database (CGRD), from the 10-year period of 1 January 2007 to 31 December 2017. We applied group-based trajectory modeling (GBTM) to identify the patterns of HbA1C trajectories, and multiple Cox proportional hazards regressions were used to estimate the hazard ratio (HR) for the risk of HZ infection with adjustment of age, sex, and comorbidities. This study enrolled 121,999 subjects to perform the analysis. The GBTM identified four HbA1C trajectories: 'good control' (58.4%), 'high decreasing' (8.9%), 'moderate control' (25.1%), and 'poor control' (7.6%) with the mean HbA1C of 6.7% (50 mmol/mol), 7.9% (63 mmol/mol), 8.4% (68 mmol/mol), and 10.7% (93 mmol/mol) respectively. The risk of HZ was significantly higher in the poor control with an HR = 1.44 (95% CI 1.26-1.64) after adjustment for confounders and comorbidities. The risk of HZ infection for the high decreasing group (initially poor then rapidly reaching optimal control) was nonsignificant compared to the good control group. In conclusion, the patients with poor glycemic control (mean HbA1C = 10.7%) had the highest risk of HZ infection. The patients with initial hyperglycemia then reaching optimal control could have a lower risk of HZ infection

Cohort · Confidence interval · Confounding · Diabetes mellitus · Glycemic · Hazard ratio · Hemoglobin · Insulin · Proportional hazards model · Acne and Rosacea Treatments and Effects · Cytomegalovirus and herpesvirus research · Herpesvirus Infections and Treatments · Medicine · Endocrinology · Internal Medicine

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