Socio-Economic and Environmental Factors Related to Spatial Differences in Human Non-Tuberculous Mycobacterial Diseases in the Czech Republic

Bibliographic Data

ID15472002
AuthorsHelena Modrá (0000-0001-6885-3489, Mendel University in Brno, corresponding author), Vít Ulmann (0000-0002-5203-8276, Public Health Institute Ostrava), Jan Caha (0000-0003-0165-0606, Mendel University in Brno), Dana Hübelová (0000-0002-2551-8792, Mendel University in Brno), Ondřej Konečný (0000-0003-3098-7726, Mendel University in Brno), Jana Svobodová (0000-0002-4527-2048, IFCOR Klinicke Laboratore Ltd., Vinicni 235, 615 00 Brno, Czech Republic), Ross Tim Weston (La Trobe University), I Pavlík (0000-0002-5771-3381, Mendel University in Brno)
Year2019
Volume16
Issue20
Pages3969-3969
Publication date2019-10-17
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph16203969
PMID31627484
OpenAlexW2981279016
LanguageEN
References cited81

Non-tuberculous mycobacteria (NTM) are ubiquitous environmental bacteria that can induce pulmonary and non-pulmonary diseases in susceptible persons. It is reported that the prevalence of NTM diseases is increasing in developed countries, but this differs by regions and countries. NTM species distribution and the rate of diseases caused by NTM vary widely in the historical territories of Moravia and Silesia (Czech Republic). This epidemiologic study of NTM diseases covers the period 2012-2018, reviews isolates obtained from patients with clinical disease and investigates correlations with related socio-economic and environmental factors. Individual NTM patients were included only once during the studied period and results were presented as incidence rate per year. The most frequently isolated NTM meeting the microbiological and clinical criteria in the study were the Mycobacterium avium-intracellulare complex, followed by Mycobacterium kansasii and M ycobacterium xenopi . A previously described endemic incidence of M. kansasii in the Karviná district and M. xenopi in the Ostrava district was also observed in this study. The incidence of NTM patients in the whole studied territory was 1.10/100,000 inhabitants (1.33/100,000 in men and 0.88/100,000 in women). The annual incidence of lymphadenitis in children (≤5 years of age) was 2.35/100,000 of the population of children during the 7 year period but increased in the year 2018 to 5.95/100,000. The rate of human tuberculosis in the studied area was 1.97/100,000 inhabitants. The incidence of NTM pulmonary diseases correlated with a lower socio-economic status ( r = 0.63) and a higher concentration of benzo[a]pyrene pollution in the air ( r = 0.64)

Czech · Environmental health · Environmental protection · Geography · Pathology · Tuberculosis · Medicine · Mycobacterium research and diagnosis · Tuberculosis Research and Epidemiology

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