Evaluation of Preventive Treatment Protocols for Patients under Antiresorptive Therapy Undergoing Tooth Extraction at a Swiss University Clinic
Bibliographic Data
| ID | 15472239 |
|---|---|
| Authors | Ellen Pick (University of Zurich), Nicolas Leuenberger (0000-0001-7106-6304, University of Zurich), Irina Kuster (0000-0001-9698-1330, University of Zurich), Nicole Selina Stutzmann (University of Zurich), Bernd Stadlinger (University of Zurich), Silvio Valdec (0000-0002-8029-180X, Universidade de São Paulo, corresponding author) |
| Year | 2021 |
| Volume | 18 |
| Issue | 18 |
| Pages | 9924-9924 |
| Publication date | 2021-09-21 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph18189924 |
| PMID | 34574862 |
| OpenAlex | W3199080619 |
| Language | EN |
| References cited | 28 |
Antiresorptive agent-related osteonecrosis of the jaw (ARONJ) is a dreaded complication in patients with compromised bone metabolism. The purpose of the present study was to examine the occurrence of ARONJ and its related factors among patients with a history of antiresorptive therapy undergoing tooth extraction using preventive protocols at a Swiss university clinic. Data were retrospectively pooled from health records of patients having received a surgical tooth extraction between January 2015 and April 2020 in the Clinic of Cranio-Maxillofacial and Oral surgery, University of Zurich. A total of 970 patients received an extraction with flap elevation or wound closure during this period. A total of 104 patients could be included in the study. Furthermore, variables including age, gender, smoking, risk profile, choice, indication and duration of antiresorptive therapy, number of extractions, extraction site, surgical technique, choice and duration of antibiotics as well as the presence of postoperative inflammatory complications were assessed. Overall, 4 patients developed ARONJ (incidence of 3.8%) after tooth extraction at the same location, without previous signs of osteonecrosis. Preventive methods included predominantly primary wound closure using a full thickness mucoperiosteal flap and prolonged perioperative antibiotic prophylaxis. In accordance with current literature, the applied protocol showed a reliable outcome in preventing ARONJ when a tooth extraction is required
Antibiotic prophylaxis · Antibiotics · Bisphosphonate · Complication · Dental extraction · Incidence (geometry · Oral and maxillofacial surgery · Osteonecrosis of the jaw · Osteoporosis · Perioperative · Bone and Joint Diseases · Bone health and treatments · Dentistry · Medicine · Osteomyelitis and Bone Disorders Research · Internal Medicine · Surgery
| Highly cited | No |
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