Scoping Review—The Association between Asthma and Environmental Chemicals

Bibliographic Data

ID15475211
AuthorsTiina Mattila (0000-0001-8466-985X, Helsinki University Hospital, corresponding author), Tiina Santonen (0000-0002-8150-4985, Finnish Institute of Occupational Health), Helle Raun Andersen (0000-0002-9184-3593, University of Southern Denmark), Andromachi Katsonouri (0000-0003-2038-0648, Ministry of Health), Tamás Szigeti (0000-0001-5078-9503, National Public Health and Medical Officer Service), Maria Uhl (0000-0001-5406-3718, Environment Agency Austria), Wojciech Wąsowicz (0000-0002-2991-9040, Nofer Institute of Occupational Medicine), Rosa Lange (0000-0001-6551-6719, German Environment Agency), Blesneac Ilona Beatrice (0000-0002-6503-6026, Istituto Superiore di Sanità), Beatrice Bocca (Department of Environment and Health, Istituto Superiore di Sanità, 00161 Rome, Italy), Flavia Ruggieri (0000-0002-5161-8615, Istituto Superiore di Sanità), Marike Kolossa‐Gehring (0000-0001-8644-7564, German Environment Agency), Dimosthenis Sarigiannis (0000-0003-2514-314X, Aristotle University of Thessaloniki), Denis A Sarigiannis (Technologies Division, Environmental Engineering Laboratory Department of Chemical Engineering and HERACLES Research Center on the Exposome and Health Center for Interdisciplinary Research and Innovation, Aristotle University, GR-54124 Thessaloniki, Greece), Hanna Tolonen (0000-0003-3121-4303, Finnish Institute for Health and Welfare)
Year2021
Volume18
Issue3
Pages1323-1323
Publication date2021-02-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph18031323
PMID33535701
OpenAlexW3128629820
LanguageEN
Citations received3
References cited61

Asthma is one of the most common chronic diseases worldwide affecting all age groups from children to the elderly. In addition to other factors such as smoking, air pollution and atopy, some environmental chemicals are shown or suspected to increase the risk of asthma, exacerbate asthma symptoms and cause other respiratory symptoms. In this scoping review, we report environmental chemicals, prioritized for investigation in the European Human Biomonitoring Initiative (HBM4EU), which are associated or possibly associated with asthma. The substance groups considered to cause asthma through specific sensitization include: diisocyanates, hexavalent chromium Cr(VI) and possibly p-phenylenediamine (p-PDA). In epidemiological studies, polyaromatic hydrocarbons (PAHs) and organophosphate insecticides are associated with asthma, and phthalates, per- and polyfluoroalkyl substances (PFASs), pyrethroid insecticides, mercury, cadmium, arsenic and lead are only potentially associated with asthma. As a conclusion, exposure to PAHs and some pesticides are associated with increased risk of asthma. Diisocyanates and Cr(VI) cause asthma with specific sensitization. For many environmental chemicals, current studies have provided contradicting results in relation to increased risk of asthma. Therefore, more research about exposure to environmental chemicals and risk of asthma is needed

Asthma · Biomonitoring · Environmental health · Air Quality and Health Impacts · Chemistry · Effects and risks of endocrine disrupting chemicals · Medicine · Toxic Organic Pollutants Impact · Environmental Chemistry · Immunology

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