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Did the New French Regulation of Zolpidem Decrease the Problematic Consumption of Zolpidem? A Field Study among Users

Bibliographic Data

ID15475744
AuthorsEdouard-Jules Laforgue (0000-0002-7400-1212, CHU Nantes, Service de Pharmacologie Clinique—Centre d’Evaluation et d’Information sur la Pharmacovigilance-Addictovigilance, Nantes Université, F-44000 Nantes, France), Edouard‐Jules Laforgue (Université de Tours, corresponding author), Morgane Rousselet (0000-0003-4027-7963, Université de Tours), Antoine Claudon (Nantes Université), Aurélie Aquizerate (0000-0003-2755-6490, Nantes Université), Pascale Jolliet (0000-0003-0191-9249, Université de Tours), Marion Istvan (0000-0001-7386-3075, Université de Tours), Caroline Victorri‐Vigneau (0000-0002-3745-2532, Université de Tours)
Year2022
Volume19
Issue15
Pages8920-8920
Publication date2022-07-22
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph19158920
PMID35897285
OpenAlexW4286587400
LanguageEN
References cited22

Background: The French national drug regulatory authority stated, in 2017, that a secured prescription pad must be used for zolpidem prescriptions. This study aimed to evaluate the evolution of the problematic consumption of zolpidem at the individual level since the new regulation. Methods: Two nationwide populations of at-risk users of zolpidem were recruited: one in general practitioner (GP) offices and one in specialized care centers dedicated to drug dependence (SCDDs). Participants were asked about their zolpidem consumption before and after the regulation change. The primary outcome was the evolution of problematic zolpidem consumption, as defined by at least one of the following criteria: overconsumption, fraudulent ways of obtaining, effects sought other than hypnotic, and modes of administration other than oral. Results: A total of 243 participants were included: 125 from GP offices and 118 from SCDDs. In the GP population, the prevalence of patients who were identified as problematic consumers decreased from 24.8% to 20.8% (p = 0.593), whereas the prevalence decreased from 73.7% to 51.7% in the SCDD population (p < 0.001). The most prevalent criteria for problematic status were overconsumption and fraudulent ways. Conclusions: The new French regulation of zolpidem had different impacts among two different populations of at-risk zolpidem consumers

Consumption (sociology · Economics · Environmental health · Insomnia · Medical prescription · Overconsumption · Population · Psychiatry · Sociology · Zolpidem · Medicine · Opioid Use Disorder Treatment · Pain Management and Placebo Effect · Pharmaceutical Practices and Patient Outcomes · Psychology · Pharmacology

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    American Psychiatric Association American Psychiatric Association, Ewer Ewer•Diagnostic And Statistical Manual…•2013

  • Regulatory Framework Implementation for the Prescription of Zolpidem in France, What Impact in the Older People

    Open Access•Alexandra Jobert, Marion Istvan et al.•International Journal of…•2021

Citation velocityhistorical
Highly citedNo

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