Effects of Montmorency Tart Cherry and Blueberry Juice on Cardiometabolic Outcomes in Healthy Individuals
Protocol for a 3-Arm Placebo Randomized Controlled Trial
Bibliographic Data
| ID | 15477477 |
|---|---|
| Authors | Jonathan Sinclair (0000-0002-2231-3732, University of Lancashire, corresponding author), Gareth Shadwell (University of Lancashire), Stephanie Dillon (0000-0002-3369-8199, University of Lancashire), Robert Allan (0000-0003-4847-0194, University of Lancashire), Bobbie Butters (University of Lancashire), Lindsay Bottoms (0000-0003-4632-3764, University of Hertfordshire) |
| Year | 2021 |
| Volume | 18 |
| Issue | 18 |
| Pages | 9759-9759 |
| Publication date | 2021-09-16 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph18189759 |
| PMID | 34574679 |
| OpenAlex | W3201046324 |
| Language | EN |
| Citations received | 1 |
| References cited | 55 |
Cardiometabolic disease is recognized as the predominant cause of global mortality and healthcare expenditure. Whilst pharmaceutical interventions are effective in the short term, their long-term efficacy remain equivocal and their associated side-effects are concerning. Owing to their high levels of anthocyanins, Montmorency tart cherries and blueberries have been cited as potentially important natural treatment/preventative modalities for cardiometabolic disease. This study proposed a randomized controlled trial, aims to test the effects of consumption of Montmorency tart cherry and blueberry juice on cardiometabolic outcomes compared to placebo. This 20-day, parallel, single-blind, randomized, placebo-controlled trial will recruit 45 individuals, who will be assigned to receive 60 mL per day of either Montmorency tart cherry juice, blueberry juice or a cherry/blueberry flavoured placebo. The primary study outcome is the between-group difference in systolic blood pressure from baseline to post-intervention. Secondary outcome measures will be between-group differences in anthropometric, energy expenditure and substrate oxidation (during rest and physical activity), haematological, blood pressure/resting heart rate, psychological wellbeing and sleep efficacy indices. Statistical analysis will be conducted on an intention-to-treat basis. This study has been granted ethical approval by the University of Central Lancashire, Health Research Ethics Committee (ref: HEALTH 0016) and formally registered as a trial. Dissemination of the study findings from this investigation will be through publication in a leading peer-reviewed journal
Alternative medicine · Anthropometry · Blood pressure · Physical therapy · Placebo · Psychological intervention · Randomized controlled trial · Diet and metabolism studies · Dietary Effects on Health · Heart Rate Variability and Autonomic Control · Medicine · Nursing · Internal Medicine
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| Citations per year | 0.25 |
|---|---|
| Citation span | 2022 - 2022 (1) |
| Highly cited | No |