Soft Tissue Ewing Sarcoma Cell Drug Resistance Revisited
A Systems Biology Approach
Bibliographic Data
| ID | 15478971 |
|---|---|
| Authors | Seyedehsadaf Asfa (0000-0001-9134-7517, Izmir University), Halil Ibrahim Toy (0000-0001-7827-1546, Izmir University), Reza Arshinchi Bonab (Izmir University), George P Chrousos (0000-0002-3098-5264, National and Kapodistrian University of Athens), Athanasia Pavlopoulou (0000-0002-0815-3808, Izmir University, corresponding author), Styliani Geronikolou (0000-0003-1227-5274, National and Kapodistrian University of Athens, corresponding author) |
| Year | 2023 |
| Volume | 20 |
| Issue | 13 |
| Pages | 6288-6288 |
| Publication date | 2023-07-03 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph20136288 |
| PMID | 37444135 |
| OpenAlex | W4383069090 |
| Language | EN |
| References cited | 4 |
Ewing sarcoma is a rare type of cancer that develops in the bones and soft tissues. Drug therapy represents an extensively used modality for the treatment of sarcomas. However, cancer cells tend to develop resistance to antineoplastic agents, thereby posing a major barrier in treatment effectiveness. Thus, there is a need to uncover the molecular mechanisms underlying chemoresistance in sarcomas and, hence, to enhance the anticancer treatment outcome. In this study, a differential gene expression analysis was conducted on high-throughput transcriptomic data of chemoresistant versus chemoresponsive Ewing sarcoma cells. By applying functional enrichment analysis and protein-protein interactions on the differentially expressed genes and their corresponding products, we uncovered genes with a hub role in drug resistance. Granted that non-coding RNA epigenetic regulators play a pivotal role in chemotherapy by targeting genes associated with drug response, we investigated the non-coding RNA molecules that potentially regulate the expression of the detected chemoresistance genes. Of particular importance, some chemoresistance-relevant genes were associated with the autonomic nervous system, suggesting the involvement of the latter in the drug response. The findings of this study could be taken into consideration in the clinical setting for the accurate assessment of drug response in sarcoma patients and the application of tailored therapeutic strategies
Bioinformatics · Biology · Computational biology · Drug · Drug resistance · Epigenetics · Gene · Gene expression · Pathology · Sarcoma · Soft tissue sarcoma · Transcriptome · Cancer-related molecular mechanisms research · Medicine · RNA modifications and cancer · RNA Research and Splicing · Cancer Research · Genetics · Pharmacology
| Highly cited | No |
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