Plasma Xanthine Oxidoreductase Activity Is Associated with a High Risk of Cardiovascular Disease in a General Japanese Population

Bibliographic Data

ID15479112
AuthorsYuka Kotozaki (0000-0002-4659-1200, Iwate Medical University), Mamoru Satoh (0000-0002-2165-3153, Iwate Medical University, corresponding author), Kozo Tanno (0000-0002-1264-0684, Iwate Medical University), Hideki Ohmomo (0000-0002-3524-6524, Iwate Medical University), Ryo Otomo (Iwate Medical University), Fumitaka Tanaka (0000-0002-3520-3305, Iwate Medical University), Takahito Nasu (0000-0001-5631-6870, Iwate Medical University), Satoru Taguchi (0000-0002-1291-4294, Iwate Medical University), Hiroto Kikuchi (0000-0003-2613-5483, Iwate Medical University), Takamasa Kobayashi (0000-0002-8370-5131, Iwate Medical University), Atsushi Shimizu (0000-0001-8307-2461, Iwate Medical University), Kiyomi Sakata (0000-0003-1812-2906, Iwate Medical University), Jiro Hitomi (Iwate Medical University), Kenji Sobue (Iwate Medical University), Makoto Sasaki (0000-0002-3108-4361, Iwate Medical University)
Year2021
Volume18
Issue4
Pages1894-1894
Publication date2021-02-16
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph18041894
PMID33669298
OpenAlexW3130062561
LanguageEN
References cited29

The purpose of this study was to investigate the association between xanthine oxidoreductase (XOR) activity and a high risk of cardiovascular disease (CVD) in a general Japanese population. The Iwate Tohoku Medical Megabank Organization pooled individual participant data from a general population-based cohort study in Iwate prefecture. The cardiovascular risk was calculated using the Framingham Risk Score (FRS). A total of 1605 of the 1631 participants (98.4%) had detectable XOR activity. Multiple regression analysis demonstrated that XOR activity was independently associated with body mass index (β = 0.26, p p p = 0.001), and uric acid (β = 0.13, p p = 0.008). XOR activity is associated with a high risk for CVD, suggesting that high XOR activity may indicate cardiovascular risk in a general Japanese population

Body mass index · Confidence interval · Disease · Dyslipidemia · Environmental health · Framingham Risk Score · Population · Quartile · Uric acid · Alcohol Consumption and Health Effects · Gout, Hyperuricemia, Uric Acid · Inflammasome and immune disorders · Medicine · Endocrinology · Gastroenterology · Internal Medicine

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