Treatment Adherence and Health-Related Quality of Life in Patients with Hemophilia in Hong Kong
Bibliographic Data
| ID | 15479159 |
|---|---|
| Authors | Yin Ting Cheung (0000-0001-9874-8938, Chinese University of Hong Kong, corresponding author), Pok Hong Lam (Chinese University of Hong Kong), Henry Hon Wai Lam (0000-0003-3560-2442, Hong Kong Haemophilia Society, Hong Kong, China), Chung-Tin Ma (Chinese University of Hong Kong), Alex Wing Kwan Leung (0000-0001-9781-5908, Chinese University of Hong Kong), Raymond Wong (0000-0002-6963-9924), Raymond Siu Ming Wong (0000-0002-9011-4268, Chinese University of Hong Kong), Chi Kong Li (0000-0002-2810-5758, Chinese University of Hong Kong) |
| Year | 2022 |
| Volume | 19 |
| Issue | 11 |
| Pages | 6496-6496 |
| Publication date | 2022-05-26 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph19116496 |
| PMID | 35682087 |
| OpenAlex | W4281628033 |
| Language | EN |
| References cited | 48 |
Background: This study aims to identify factors affecting health-related quality of life (HRQoL) in Chinese patients with hemophilia in Hong Kong, and to examine the association between treatment adherence and HRQoL outcomes. Methods: Patients with hemophilia A or B from a non-governmental organization reported their HRQoL and treatment adherence to prophylactic therapy using validated tools. Univariate tests and multivariable regression analysis were used to compare differences in outcomes across clinically relevant subgroups. Results: Fifty-six patients were recruited (mean age 30.4 [17.4] years; majority hemophilia A: 75%; moderate-to-severe severity: 88%). Patients who received prophylactic treatment reported fewer work/school problems (25.8 [18.9] versus 51.5 [26.3]; p = 0.001) than those who received on-demand therapy. The multivariable model showed that older age (B = 0.42, 95% CI = 0.093−0.75) and living in public housing (B = 10.24, 95% CI = 0.70−19.77) were associated with worse HRQoL. Older age was associated with treatment non-adherence (r = 0.66, p < 0.0001). Patients with poor adherence tended to report worse functioning in sports/leisure (r = 0.31, p = 0.033). Conclusions: Our results suggest that patients who were older, had lower education attainment and received on-demand treatment had poorer perception of their health. Improving adherence may lead to better HRQoL. Future work includes evaluating the occupational needs prospectively in this population
Environmental health · Multivariate analysis · Physical therapy · Population · Public health · Quality of life (healthcare · Univariate analysis · Cancer-related gene regulation · Hemophilia Treatment and Research · Medicine · Gerontology · Internal Medicine · Pediatrics
| Citation velocity | historical |
|---|---|
| Highly cited | No |