Association between Anemia Severity and Ischemic Stroke Incidence

A Retrospective Cohort Study

Bibliographic Data

ID15480225
AuthorsHuifen Chen (0000-0002-6630-7035), Hui-Fen Chen (Buddhist Tzu Chi Medical Foundation), Tsing‐Fen Ho (0000-0003-1061-6880, Central Taiwan University of Science and Technology, corresponding author), Yu‐Hung Kuo (0000-0002-7506-6878, Taipei Tzu Chi Hospital), Yu-Hung Kuo (Buddhist Tzu Chi Medical Foundation), Ju‐Huei Chien (0000-0003-4971-5616, Taipei Tzu Chi Hospital, corresponding author)
Year2023
Volume20
Issue5
Pages3849-3849
Publication date2023-02-21
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph20053849
PMID36900859
OpenAlexW4321497398
LanguageEN
References cited40

Stroke patients presenting with anemia at the time of stroke onset had a higher risk of mortality and development of other cardiovascular diseases and comorbidities. The association between the severity of anemia and the risk of developing a stroke is still uncertain. This retrospective study aimed to evaluate the association between stroke incidence and anemia severity (by WHO criteria). A total of 71,787 patients were included, of whom 16,708 (23.27%) were identified as anemic and 55,079 patients were anemia-free. Female patients (62.98%) were more likely to have anemia than males (37.02%). The likelihood of having a stroke within eight years after anemia diagnosis was calculated using Cox proportional hazard regression. Patients with moderate anemia had a significant increase in stroke risk compared to the non-anemia group in univariate analyses (hazard ratios [HR] = 2.31, 95% confidence interval [CI], 1.97-2.71, p p = 0.032). The data reveal that patients with severe anemia received more anemia treatment, such as blood transfusion and nutritional supplementation, and maintaining blood homeostasis may be important to preventing stroke. Anemia is an important risk factor, but other risk factors, including diabetes and hyperlipidemia, also affect stroke development. There is a heightened awareness of anemia's severity and the increasing risk of stroke development

Anemia · Confidence interval · Hazard ratio · Incidence (geometry · Multivariate analysis · Proportional hazards model · Retrospective cohort study · Risk factor · Stroke (engine · Univariate analysis · Erythropoietin and Anemia Treatment · Hemoglobinopathies and Related Disorders · Iron Metabolism and Disorders · Medicine · Internal Medicine

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