The Nicotine Metabolite Ratio and Response to Smoking Cessation Treatment Among People Living with HIV Who Smoke in South Africa
Bibliographic Data
| ID | 15480310 |
|---|---|
| Authors | Chukwudi Keke (Colorado State University, corresponding author), Limakatso Lebina (0000-0001-6825-0573, Africa Health Research Institute), Katlego Motlhaoleng (0000-0001-7644-1038, Perinatal HIV Research Unit), Raymond Niaura (0000-0002-0856-3540, New York University), David B Abrams (0000-0002-0868-4350, New York University), Ebrahim Variava (0000-0003-2888-789X), Nikhil Gupte (0000-0002-6688-2478, Johns Hopkins Medicine), Jonathan E Golub (0000-0003-2398-3145, Johns Hopkins University), Neil Martinson (0000-0002-0184-5705, Perinatal HIV Research Unit), Jessica L Elf (0000-0002-4298-6395, Colorado State University) |
| Year | 2025 |
| Volume | 22 |
| Issue | 7 |
| Pages | 1040-1040 |
| Publication date | 2025-06-30 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph22071040 |
| PMID | 40724106 |
| OpenAlex | W4411824604 |
| Language | EN |
| References cited | 8 |
The nicotine metabolite ratio (NMR) has been informative in selecting treatment choices for nicotine dependence and increasing treatment efficacy in Western settings; however, the clinical utility of the NMR among smokers in low-resource settings remains unclear. Prospective analysis was conducted using data from a randomized controlled trial of smoking cessation among adults living with HIV, to examine the association between the NMR and response to smoking cessation treatment. NMR was assessed using bio-banked urine samples collected at baseline. Self-reported smoking at 6 months was verified using a urine cotinine test and exhaled breath carbon monoxide (CO). We found no associations between the NMR and smoking abstinence (adjusted risk ratio (aRR) = 0.82; 95% CI: 0.45, 1.49; p = 0.53). No evidence of effect modification by treatment conditions was observed on the multiplicative scale (aRR = 1.17; 95% CI: 0.32, 4.30; p = 0.81) or additive scale (adjusted relative excess risk due to interaction (aRERI) = 0.10; 95% CI: -1.16, 1.36; p = 0.44). Our results suggest that the NMR may not be a viable approach for selecting smoking cessation treatment in this setting, given the minimal variability in our sample and racial/ethnic makeup of this population
Abstinence · Confidence interval · Cotinine · Environmental health · Metabolite · Nicotine · Population · Psychiatry · Relative risk · Smoking cessation · Urine · Cannabis and Cannabinoid Research · Demography · Influenza Virus Research Studies · Medicine · Smoking Behavior and Cessation · Internal Medicine
Detecting Alcoholism
Biochemical Verification of Tobacco Use and Abstinence
Measuring the Heaviness of Smoking
Recommendations for presenting analyses of effect modification and interaction
An Emerging Syndemic of Smoking and Cardiopulmonary Diseases in People Living with HIV in Africa
A Cross-Sectional Analysis of the Nicotine Metabolite Ratio and Its Association with Sociodemographic and Smoking Characteristics among People with HIV Who Smoke in South Africa
Tobacco use and nicotine dependence among people living with HIV who drink heavily in South Africa
Race, place, and HIV
| Citation velocity | historical |
|---|---|
| Highly cited | No |