Change in Oxidative Stress Biomarkers During 30 Days in Saturation Dive
A Pilot Study
Bibliographic Data
| ID | 15480359 |
|---|---|
| Authors | Simona Mrakic‐Sposta (0000-0001-7359-2690, National Research Council), Alessandra Vezzoli (0000-0002-0277-163X, National Research Council), Federica D’Alessandro (0000-0002-3693-7466, University of Padua), Matteo Paganini (0000-0002-7556-6928, University of Padua, corresponding author), Cinzia Dellanoce (0000-0002-0750-6261, National Research Council), Danilo Cialoni (0000-0001-7655-1261, University of Padua), Gerardo Bosco (0000-0001-6595-7944, University of Padua) |
| Year | 2020 |
| Volume | 17 |
| Issue | 19 |
| Pages | 7118-7118 |
| Publication date | 2020-09-28 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph17197118 |
| PMID | 32998440 |
| OpenAlex | W3088413835 |
| Language | EN |
| Citations received | 2 |
| References cited | 30 |
Saturation diving allows divers to reduce the risk of decompression sickness while working at depth for prolonged periods but may increase reactive oxygen species (ROS) production. Such modifications can affect endothelial function by exacerbating oxidative stress. This study investigated the effects of saturation diving on oxidative stress damage. Redox status was evaluated through: ROS production; total antioxidant capacity (TAC); nitric oxide metabolites (NOx); nitrotyrosine (3-NT); and lipid peroxidation (8-iso-PGF2α) assessment. Creatinine and neopterin were analyzed as markers of renal function and damage. Measurements were performed on saliva and urine samples obtained at four time points: pre; deep; post; and 24 h post. Four divers were included in the study. After the saturation dive (post), significant ( p -1 ), TAC (1.88 ± 0.03 vs. 2.01 ± 0.08 mM), NOx (207.0 ± 103.3 vs. 441.8 ± 97.3 μM), 3-NT (43.32 ± 18.03 vs. 18.64 ± 7.45 nM·L -1 ), and 8-iso-PGF2α (249.7 ± 45.1 vs. 371.9 ± 54.9 pg·mg -1 creatinine) were detected. Markers of renal damage were increased as well after the end of the saturation dive (creatinine 0.54 ± 0.22 vs. 2.72 ± 1.12 g-L -1 ; neopterin 73.3 ± 27.9 vs. 174.3 ± 20.53 μmol·mol -1 creatinine). These results could ameliorate commercial or military diving protocols or improve the understanding of symptoms caused by oxygen level elevation
Creatinine · Lipid peroxidation · Neopterin · Oxidative stress · Reactive oxygen species · Renal function · Cardiovascular and Diving-Related Complications · Chemistry · High Altitude and Hypoxia · Medicine · Spaceflight effects on biology · Biochemistry · Endocrinology · Internal Medicine
| Citations per year | 0.4 |
|---|---|
| Citation span | 2021 - 2023 (3) |
| Highly cited | No |