Assessment of a Screening Questionnaire to Identify Exposure to Lead in Pregnant Women

Lead readily crosses the placenta and displays adverse effects on birth outcomes and neurodevelopment. Systematic identification of the risk of exposure during pregnancy is essential but rarely performed, probably due to hospital staff's workload and their lack of awareness. We aimed to evaluate the relevance of a questionnaire to screen pregnant women for lead exposure. A cross-sectional, multicentre study was carried out on a population of 792 pregnant women from February 2018 to May 2020. A total of 596 women had a blood lead test: 68.5% had blood lead levels below 10 μg/L. The estimated prevalence above 25 μg/L was 4% (95% confidence interval (CI) [2.6-5.9]) and 1.3% had levels above 50 μg/L (95% CI [0.6-2.6]). Multivariate analysis showed that three risk factors significantly increased the probability of blood lead levels above 25 μg/L: the use of traditional cosmetics (adjusted odds ratio [aOR]: 3.90; 95% CI [1.65-9.21]; p = 0.002), degraded old housing (aOR: 2.67; 95% CI [1.19-6.038]; p = 0.018), and (marginally) eating bread more than twice a day (aOR: 2.40; 95% CI [0.96-6.11]; p = 0.060). Our study reveals that a three-question tool can be used to quickly screen for the risk of lead exposure in our population and to trigger lead blood tests and special vigilance during pregnancy follow-up

Blood lead level · Blood test · Confidence interval · Environmental health · Gynecology · Lead (geology · Lead exposure · Lead poisoning · Obstetrics · Odds ratio · Population · Pregnancy · Environmental Justice and Health Disparities · Heavy Metal Exposure and Toxicity · Medicine · Mercury impact and mitigation studies · Internal Medicine