Characterization of Gut Microbiota Composition in Type 2 Diabetes Patients

A Population-Based Study

Bibliographic Data

ID15480876
AuthorsIsabella Polidori (0000-0003-3398-4133, Lifebrain srl Cerba Healthcare, Guidonia Montecelio, 190/A Viale Roma, 00012 Rome, Italy), Laura Marullo (Lifebrain Nocera Cerba Healthcare, 84014 Nocera Inferiore, Italy), Cristiano Ialongo (0000-0002-2816-7107, Sapienza University of Rome), Flaminia Tomassetti (0000-0002-6336-814X, University of Rome Tor Vergata), Roberto Colombo (0000-0003-4900-1234, Lifebrain srl Cerba Healthcare, Guidonia Montecelio, 190/A Viale Roma, 00012 Rome, Italy), Francesca Di Gaudio (0000-0002-5910-5750, University of Palermo), Graziella Calugi (0009-0007-6001-1552, Lifebrain srl Cerba Healthcare, Guidonia Montecelio, 190/A Viale Roma, 00012 Rome, Italy), Giulia Marrone (0000-0002-5854-2086, University of Rome Tor Vergata), Annalisa Noce (0000-0003-1310-3730, University of Rome Tor Vergata), Sergio Bernardini (0000-0003-1984-6834, University of Rome Tor Vergata), Francesco Broccolo (0000-0003-1297-2598, University of Milano-Bicocca), Massimo Pieri (0000-0002-3463-0268, University of Rome Tor Vergata, corresponding author)
Year2022
Volume19
Issue23
Pages15913-15913
Publication date2022-11-29
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph192315913
PMID36497987
OpenAlexW4311040523
LanguageEN
Citations received1
References cited36

(1) Background: A clinical laboratory index to assess gut dysbiosis is the F/B ratio < 0.8. In fact, an elevated proportion of Firmicutes and a reduced population of Bacteroides in diabetes type 2 (T2D) subjects has been observed. This study aimed to detail the dysbiosis status in the Italian population, focusing on some pathogenic spectra (T2D) or metabolic disorders. (2) Material and methods: A quantity of 334 fecal samples was analyzed in order to perform genetic testing and sequencing. (3) Results: A trend in over imbalance was observed in the percentage of Proteobacteria (median value: 6.75%; interquartile range (IQR): 3.57−17.29%). A statistically significant association (χ2p = 0.033) was observed between type of dysbiosis and T2D, corresponding to an Odds Ratio (OR) of 1.86. It was noted that females with cystitis/candidiasis are significantly prevalent in T2D patients (p < 0.01; OR: 3.59; 95% CI: 1.43−8.99). Although, in non-diabetic males, a sugar craving is significantly associated with the rate of dysbiosis in non-diabetic males (p < 0.05; OR 1.07; 95% CI 1.00−1.16). (4) Conclusion: In T2D patients, the Bacteroidetes/Firmicutes ratio was biased in favor of Proteobacteria, to be expected due to the nutritional habits of the patients. Thus, T2D females had altered gut permeability favoring the development of infections in the vaginal tract

Bacteria · Bacteroides · Bacteroidetes · Biology · Diabetes mellitus · Dysbiosis · Feces · Firmicutes · Gut flora · Interquartile range · Odds ratio · Population · Type 2 diabetes · Clostridium difficile and Clostridium perfringens research · Gastrointestinal motility and disorders · Gut microbiota and health · Medicine · Endocrinology · Gastroenterology · Genetics · Immunology · Internal Medicine · Microbiology · Physiology

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