Environmental Exposure to Trace Elements and Prostate Cancer in Three New Zealand Ethnic Groups
Bibliographic Data
| ID | 15480892 |
|---|---|
| Authors | Marion A Gray (0000-0002-0482-7350, James Cook University, corresponding author), Jose A Centeno (0000-0002-1202-0493, Armed Forces Institute of Pathology), David Slaney (University of Otago), David P Slaney (University of Otago), John W Ejnik (Northern Michigan University), Todor I Todorov (0000-0002-5014-7647, Armed Forces Institute of Pathology), Todor Todorov (0000-0002-6275-476X, Armed Forces Institute of Pathology), John N Nacey (University of Otago) |
| Year | 2005 |
| Volume | 2 |
| Issue | 3 |
| Pages | 374-384 |
| Publication date | 2005-12-30 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph2005030001 |
| PMID | 16819092 |
| OpenAlex | W2113172552 |
| Language | EN |
| References cited | 47 |
A stratified random sample of 176 men was taken from a larger community prostate study group of 1405 eligible subjects from three ethnic groups in the Wellington region of New Zealand, in order to examine ethnic differences in exposure to cadmium (Cd), selenium (Se) and zinc (Zn) and possible associations of blood levels of Cd, Se and Zn with the prevalence of elevated serum Prostate Specific Antigen (PSA); a marker of prostate cancer. Maori and Pacific Islands men were found likely to have higher Cd exposure than New Zealand Europeans through diet, occupation and smoking. However, there was no significant difference between ethnic groups in mean blood Cd levels. Pacific Islands men had significantly higher levels of blood Se than both New Zealand European men and Maori men. Maori men had significantly higher levels of blood Zn than both New Zealand European men and Pacific Islands men. A positive association was found between blood Cd and total serum PSA. Se and Zn levels were not associated with elevated PSA. Maori and Pacific Islands men have higher prostate cancer mortality rates than New Zealand European men. Ethnic differences in mortality could be contributed to by differences in rates of disease progression, influenced by exposure and/or deficiency to trace elements. However, results did not reflect a consistent ethnic trend and highlight the complexity of the risk/protective mechanisms conferred by exposure factors. Further research is needed to ascertain whether the associations found between Cd and PSA levels are biologically important or are merely factors to be considered when interpreting PSA results clinically
Cancer · Ethnic group · Prostate cancer · Prostate-specific antigen · Demography · Heavy Metal Exposure and Toxicity · Medicine · Mercury impact and mitigation studies · Trace Elements in Health · Gerontology · Internal Medicine · Physiology
| Highly cited | No |
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