Toxic Effects of the Mixture of Phthalates and Bisphenol A—Subacute Oral Toxicity Study in Wistar Rats
Bibliographic Data
| ID | 15481998 |
|---|---|
| Authors | Katarina Baralić (0000-0003-3290-2204, University of Belgrade, corresponding author), Aleksandra Buha Djordjević (0000-0002-6942-7040, University of Belgrade), Katarina Živančević (0000-0002-2369-3060, University of Belgrade), Evica Antonijević Miljaković (0000-0003-3430-9615, University of Belgrade), Milena Anđelković (University of Belgrade), Dragana Javorac (University of Belgrade), Marijana Ćurčić (0000-0003-4028-3108, University of Belgrade), Zorica Bulat (0000-0001-9830-8772, University of Belgrade), Biljana Antonijević (0000-0002-3996-454X, University of Belgrade), Danijela Đukić-Ćosić (0000-0003-1618-9154, University of Belgrade) |
| Year | 2020 |
| Volume | 17 |
| Issue | 3 |
| Pages | 746-746 |
| Publication date | 2020-01-23 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph17030746 |
| PMID | 31979393 |
| OpenAlex | W3001702632 |
| Language | EN |
| Citations received | 3 |
| References cited | 75 |
Phthalates and bisphenol A, classified as endocrine disruptors, have weak estrogenic, anti-androgenic properties, and affect thyroid hormone regulation. The aim of this study on male rats was to compare the subacute toxic effects of low doses of single compounds (bis (2 -ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and bisphenol A (BPA)) with the effects of their mixture through different biochemical, hormonal, and hematological parameters. Rats were divided into five experimental groups: Control (corn oil), DEHP (50 mg/kg b.w./day), DBP (50 mg/kg b.w./day), BPA (25 mg/kg b.w./day), and MIX (50 mg/kg b.w./day DEHP + 50 mg/kg b.w/day DBP + 25 mg/kg b.w./day BPA). Animals were sacrificed after 28 days of oral treatment and blood was collected for further analysis. The results demonstrated that the mixture produced significant changes in lipid profile, liver-related biochemical parameters, and glucose level. Furthermore, the opposite effects of single substances on the thyroxine level have been shown in comparison with the mixture, as well as a more pronounced effect of the mixture on testosterone level. This study contributes to the body of knowledge on the toxicology of mixtures and gives one more evidence of the paramount importance of mixture toxicity studies, especially in assessing the endocrine disruptive effects of chemicals
Benzhydryl compounds · Bisphenol · Bisphenol A · Corn oil · Dibutyl phthalate · Endocrine disruptor · Endocrine system · Hormone · Phthalate · Testosterone (patch · Toxicity · Toxicokinetics · Chemistry · Effects and risks of endocrine disrupting chemicals · Medicine · Biochemistry · Endocrinology · Food Science · Internal Medicine · Organic Chemistry · Physiology
Prenatal PFAS exposure and offspring health
Association of Serum Levels of Plasticizers Compounds, Phthalates and Bisphenols, in Patients and Survivors of Breast Cancer
Toxicological Assessment of Oral Co-Exposure to Bisphenol A (BPA) and Bis(2-ethylhexyl) Phthalate (Dehp) in Juvenile Rats at Environmentally Relevant Dose Levels
| Citations per year | 0.6 |
|---|---|
| Citation span | 2021 - 2026 (6) |
| Highly cited | No |