Socioeconomic, Ethnocultural, Substance- and Cannabinoid-Related Epidemiology of Down Syndrome USA 1986–2016

Combined Geotemporospatial and Causal Inference Investigation

Bibliographic Data

ID15484181
AuthorsAlbert Stuart Reece (0000-0002-3256-720X, Edith Cowan University, corresponding author), Gary Kenneth Hulse (0000-0002-7907-0233, Edith Cowan University), Gary Hulse (The University of Western Australia)
Year2022
Volume19
Issue20
Pages13340-13340
Publication date2022-10-16
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph192013340
PMID36293924
OpenAlexW4306382095
LanguageEN
References cited61

Data show that the association between DSR and substance- and cannabinoid- exposure is robust to multivariable geotemporospatial adjustment, implicate particularly cannabigerol and Δ9-tetrahydrocannabinol, and fulfil quantitative epidemiological criteria for causality. Nevertheless, detailed experimental studies would be required to formally demonstrate causality. Cannabis legalization was associated with elevated DSR's at both bivariate and multivariable analysis. Findings are consistent with those from Hawaii, Colorado, Canada, Australia and Europe and concordant with several cellular mechanisms. Given that the cannabis industry is presently in a rapid growth-commercialization phase the present findings linking cannabis use with megabase scale genotoxicity suggest unrecognized DS risk factors, are of public health importance and suggest that re-focussing the cannabis debate on multigenerational health concerns is prudent

Cannabis · Environmental health · Ethnic group · Population · Psychiatry · Substance abuse · Data-Driven Disease Surveillance · Demography · Medicine · Occupational and environmental lung diseases · Epidemiology · Internal Medicine

Tools

Open DOIOpen Access