Potential Effects of Long-Term Exposure to Air Pollution on Dementia

A Longitudinal Analysis in American Indians Aged 55 Years and Older

Bibliographic Data

ID15484309
AuthorsYachen Zhu (0000-0002-8192-6168, University of California, Irvine), Yuxi Shi (0000-0002-4691-9595, University of California, Irvine), Scott M Bartell (0000-0001-7797-2906, University of California, Irvine), Maria M Corrada (0000-0002-8168-8593, University of California, Irvine), M Manson (0000-0001-6194-1961, Colorado School of Public Health), Joan O’connell (0000-0003-3498-1153, Colorado School of Public Health), Luohua Jiang (0000-0002-2281-7260, University of California, Irvine, corresponding author)
Year2024
Volume21
Issue2
Pages128-128
Publication date2024-01-24
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph21020128
PMID38397619
OpenAlexW4391225485
LanguageEN
References cited45

(1) Background: American Indians are disproportionately affected by air pollution, an important risk factor for dementia. However, few studies have investigated the effects of air pollution on the risk of dementia among American Indians. (2) Methods: This retrospective cohort study included a total of 26,871 American Indians who were 55+ years old in 2007, with an average follow-up of 3.67 years. County-level average air pollution data were downloaded from land-use regression models. All-cause dementia was identified using ICD-9 diagnostic codes from the Indian Health Service's (IHS) National Data Warehouse and related administrative databases. Cox models were employed to examine the association of air pollution with dementia incidence, adjusting for co-exposures and potential confounders. (3) Results: The average PM 2.5 levels in the IHS counties were lower than those in all US counties, while the mean O 3 levels in the IHS counties were higher than the US counties. Multivariable Cox regressions revealed a positive association between dementia and county-level O 3 with a hazard ratio of 1.24 (95% CI: 1.02-1.50) per 1 ppb standardized O 3 . PM 2.5 and NO 2 were not associated with dementia risk after adjusting for all covariates. (4) Conclusions: O 3 is associated with a higher risk of dementia among American Indians

Air pollution · Dementia · Environmental health · Longitudinal study · Sociology · Term (time · Air Quality and Health Impacts · Demography · Energy and Environment Impacts · Health, Environment, Cognitive Aging · Medicine · Psychology · Ecology · Gerontology

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