Sars-CoV-2 Infection in Pregnancy
Placental Histomorphological Patterns, Disease Severity and Perinatal Outcomes
Bibliographic Data
| ID | 15487540 |
|---|---|
| Authors | Yin Ping Wong (0000-0003-4897-9927, National University of Malaysia, corresponding author), Geok Chin Tan (0000-0002-2289-7619, National University of Malaysia, corresponding author), Siti Zarqah Omar (Hospital Sultanah Nur Zahirah), Muaatamarulain Mustangin (0000-0003-3834-7520, National University of Malaysia), Yogesh Singh (0000-0002-9139-9736, University of Tübingen), Madhuri S Salker (0000-0002-7939-289X, University of Tübingen), Nor Haslinda Abd Aziz (0000-0002-4632-7135, National University of Malaysia), Mohamad Nasir Shafiee (0000-0001-5631-5309, National University of Malaysia) |
| Year | 2022 |
| Volume | 19 |
| Issue | 15 |
| Pages | 9517-9517 |
| Publication date | 2022-08-03 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph19159517 |
| PMID | 35954874 |
| OpenAlex | W4289711074 |
| Language | EN |
| References cited | 50 |
The association between maternal COVID-19 infection, placental histomorphology and perinatal outcomes is uncertain. The published studies on how placental structure is affected after SARS-CoV-2 virus in COVID-19-infected pregnant women are lacking. We investigated the effects of maternal SARS-CoV-2 infection on placental histomorphology and pregnancy outcomes. A retrospective cohort study on 47 pregnant women with confirmed SARS-CoV-2 infection, matched with non-infected controls, was conducted. Relevant clinicopathological data and primary birth outcomes were recorded. Histomorphology and SARS-CoV-2 immunohistochemistry analyses of placental tissues were performed. Only 1 of 47 cases showed SARS-CoV-2 immunoreactivity in the syncytiotrophoblasts. Histologically, decidual vasculopathy (n = 22/47, p = 0.004), maternal vascular thrombosis (n = 9/47, p = 0.015) and chronic histiocytic intervillositis (n = 10/47, p = 0.027) were significantly higher in the COVID-19-infected placentas when compared to the control group. Maternal vascular thrombosis was a significant feature in the active COVID-19 group. A significant lower gestational age (p < 0.001)) at delivery and a higher caesarean section rate (p = 0.007) were observed in the active SARS-CoV-2-infected cases, resulting in a significant lower fetal-placental weight ratio (p = 0.022) and poorer Apgar score (p < 0.001). Notably, active (p = 0.027), symptomatic (p = 0.039), severe-critical (p = 0.002) maternal COVID-19 infection and placental inflammation (p = 0.011) were associated with an increased risk of preterm delivery. Altered placental villous maturation and severe-critical maternal COVID-19 infection were associated with an elevated risk of poor Apgar scores at birth (p = 0.018) and maternal mortality (p = 0.023), respectively
Apgar score · Biology · Fetus · Gestational age · Obstetrics · Placenta · Pregnancy · Retrospective cohort study · COVID-19 and healthcare impacts · COVID-19 Impact on Reproduction · Medicine · Pregnancy and preeclampsia studies · Internal Medicine
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| Citation velocity | historical |
|---|---|
| Highly cited | No |