Tuberculosis Transmission in Households and Classrooms of Adolescent Cases Compared to the Community in China

Bibliographic Data

ID15487812
AuthorsDongxiang Pan (0000-0003-2064-8974, Prince of Songkla University), Mei Lin (0000-0002-4625-1011, Guangxi Center for Disease Prevention and Control), Rushu Lan (0000-0002-1176-9371, Guangxi Center for Disease Prevention and Control), E A Gravi (0000-0003-1024-5813, Houston Methodist), Dingwen Lin (0000-0002-3609-3451, Guangxi Center for Disease Prevention and Control), Dabin Liang (Guangxi Center for Disease Prevention and Control), Xi Long (0000-0001-9505-1270, Guangxi Medical University), Huifang Qin (Guangxi Center for Disease Prevention and Control), Liwen Huang (0000-0001-6915-8891, Guangxi Center for Disease Prevention and Control), Minying Huang (Guangxi Center for Disease Prevention and Control), Virasakdi Chongsuvivatwong (0000-0002-9850-4463, Prince of Songkla University, corresponding author)
Year2018
Volume15
Issue12
Pages2803-2803
Publication date2018-12-10
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph15122803
PMID30544676
OpenAlexW2904269799
LanguageEN
Citations received3
References cited33

The aim of this paper is to evaluate the link between the history of exposure to tuberculosis (TB) in the household and diagnosed TB cases at school, and to compare the detection rate of active TB among household contacts and classroom contacts of adolescent TB cases with the rates among contacts of healthy controls. From November 2016 to December 2017, a prospective matched case-control study was conducted using passively identified index adolescent student cases from the TB surveillance system and healthy controls (matched by county, school type, sex, age and ethnicity). Contacts in households and classrooms of index cases and of controls were investigated. Matched tabulation of 117 case-control pairs revealed exposure to TB in the household as a strong risk factor (odds ratio (OR) = 21.0, 95% confidence interval (CI): 3.4, 868.6). Forty-five (case detection rate 0.69%) and two (case detection rate 0.03%) new active TB cases were detected among 6512 and 6480 classroom contacts of the index cases and controls, respectively. Having an index case in the classroom significantly increased the risk of classmates contracting active TB (OR = 22.5, 95% CI: 5.9, 191.4). Our findings suggested that previous exposure to TB in the household could lead a child to catch TB at school, then spread TB to classmates

Case-control study · Confidence interval · Contact tracing · Coronavirus disease 2019 (COVID-19 · Disease · Environmental health · Index (typography · Index case · Odds ratio · Transmission (telecommunications · Tuberculosis · Demography · Medicine · Pneumocystis jirovecii pneumonia detection and treatment · Pneumonia and Respiratory Infections · Tuberculosis Research and Epidemiology · Internal Medicine · Pediatrics

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