Sleep Quality Is Associated with Vitamin B12 Status in Female Arab Students

Bibliographic Data

ID15487883
AuthorsSara Al-Musharaf (0000-0002-7830-1415, King Saud University, corresponding author), Alanoud Alabdulaaly (King Saud University), Hanadi Bin Mujalli (0000-0003-2633-1572, King Saud University), Hatoun Alshehri (King Saud University), Hind Alajaji (0000-0002-4497-8890, King Saud University), Rania Bogis (0000-0001-9503-1560, King Saud University), Ruyuf Y Alnafisah (King Saud University), Ruyuf Alnafisah (King Saud University), Shaden Alfehaid (0000-0002-3623-228X, King Saud University), Hala Alhodaib (0000-0002-3551-025X, King Saud University), Alice Murphy (0000-0001-5554-1558, Nottingham Trent University), Syed Danish Hussain (King Saud University), Shaun Sabico (0000-0002-5248-2350, King Saud University), Philip G McTernan (Nottingham Trent University), Philip McTernan (Nottingham Trent University), Nasser M Al‐Daghri (0000-0001-5472-1725, King Saud University)
Year2021
Volume18
Issue9
Pages4548-4548
Publication date2021-04-25
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph18094548
PMID33922970
OpenAlexW3158166920
LanguageEN
References cited53

Studies have explored how vitamin B12 status affects sleep among elders and children, but this remains to be investigated among young adults. We used the Pittsburgh Sleep Quality Index (PSQI) to assess the association between serum vitamin B12 and sleep among female college students in Saudi Arabia. In this cross-sectional study, we enrolled 355 participants (age (years), 20.7 ± 1.5; body mass index, 23.6 kg/m 2 ± 5.2) at King Saud University, Riyadh, Saudi Arabia. Fasting blood samples were analyzed regarding the serum vitamin B12 and blood lipids. Anthropometric, socio-demographic, clinical history, stress, physical activity, and dietary data were collected. We assessed the sleep statuses of the participants using the PSQI. Around 72% of the participants were "poor" sleepers (PSQI > 5). Subgroup analysis within the tertiles showed that participants with higher vitamin B12 in the second and third tertiles reported better scores for sleep quality (B ± SE = -12.7 ± 5.6, p = 0.03; B ± SE = -32.7 ± 16.4, p = 0.05, respectively) and also reported a lower use of sleep medication (B ± SE = -21.2 ± 9.9, p = 0.03, in the second tertile only), after adjusting for the waist-hip ratio and stress. However, sleep was not found to be directly associated with either serum vitamin B12 or dietary vitamin B12. In conclusion, the serum vitamin B12 results show that the participants with higher vitamin B12 in the second and third tertiles reported better scores on the sleep quality scale and a lower use of sleep medication. However, no such associations were observed with the overall PSQI. More studies with larger sample sizes are needed to establish a direct relationship between sleep and vitamin B12

Anthropometry · Body mass index · Cross-sectional study · Insomnia · Pathology · Perceived Stress Scale · Pittsburgh Sleep Quality Index · Psychiatry · Sleep (system call · Sleep quality · Stress (linguistics · Vitamin B12 · Waist · Medicine · Obstructive Sleep Apnea Research · Sleep and related disorders · Sleep and Wakefulness Research · Internal Medicine · Physiology

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