Increased Compulsivity in Adulthood after Early Adolescence Immune Activation
Preclinical Evidence
Bibliographic Data
| ID | 15488294 |
|---|---|
| Authors | Santiago Mora (0000-0002-8237-6938, University of Almería, corresponding author), Elena Martín-González (0000-0003-4457-7402, University of Almería), Ángeles Prados-Pardo (0000-0003-0895-1313, University of Almería), Pilar Flores (0000-0001-7950-2086, University of Almería), Margarita Moreno (0000-0001-7336-6167, University of Almería, corresponding author) |
| Year | 2021 |
| Volume | 18 |
| Issue | 9 |
| Pages | 4684-4684 |
| Publication date | 2021-04-28 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph18094684 |
| OpenAlex | W3157059027 |
| Language | EN |
| References cited | 87 |
Immune activation during early developmental stages has been proposed as a contributing factor in the pathogenesis of neuropsychiatric conditions such as obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, and autism in both human and animal studies. However, its relationship with the vulnerability to inhibitory control deficit, which is a shared feature among those conditions, remains unclear. The present work studied whether postnatal immune activation during early adolescence, combined with exposure to early-life adverse events, could lead to adult vulnerability to impulsive and/or compulsive behaviors. Male Wistar rats were exposed to lipopolysaccharide (LPS) in early adolescence at postnatal day 26 (PND26). During peripuberal period, half of the animals were exposed to a mild stress protocol. In adulthood, behavioral assessment was performed with the aid of the sustained attentional 5-choice serial reaction time (5-CSRT) task, schedule-induced polydipsia (SIP), and open-field locomotor activity and novelty reactivity. Rats exposed to LPS showed more compulsive responses than their control counterparts on 5-CSRT task, although no differences were observed in SIP or locomotor responses. Our study contributes to the knowledge of the relationship between immune activation and inhibitory control deficit. Future studies should aim to disentangle how, and to what extent, immune activation impacts behavior, and to understand the role of early life mild stress
Autism · Developmental psychology · Immune system · Open field · Psychiatry · Attention Deficit Hyperactivity Disorder · Medicine · Neuroendocrine regulation and behavior · Neuroscience · Psychology · Stress Responses and Cortisol · Tryptophan and brain disorders · Immunology · Physiology
| Highly cited | No |
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