Impact of Exercise Intensity on Systemic Oxidative Stress, Inflammatory Responses, and Sirtuin Levels in Healthy Male Volunteers

Bibliographic Data

ID15488661
AuthorsSu‐Youn Cho (Yonsei University), Su-Youn Cho (Yonsei University), Young‐soo Chung (0009-0002-7558-2845), Young-Soo Chung (Department of Sports and Leisure Studies, School of Arts and Health, Myongji College, Seoul 03656, Korea), Hyoung-Ki Yoon (Soongsil University), Hee‐Tae Roh (0000-0002-3586-1666, Sun Moon University, corresponding author)
Year2022
Volume19
Issue18
Pages11292-11292
Publication date2022-09-08
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph191811292
PMID36141561
OpenAlexW4294953477
LanguageEN
References cited39

Exercise can induce anti-inflammatory and antioxidant effects, for which regulation of sirtuins (SIRTs) may be a major consideration for exercise prescription. The purpose of this study was to investigate the effects of acute aerobic exercise, in particular its intensity, on systemic oxidative stress, inflammatory responses, and SIRT levels. Twenty healthy, untrained males were recruited and randomly assigned to moderate-intensity (MI, 65% VO 2 max, n = 10) and high-intensity (HI, 85% VO 2 max, n = 10) exercise. Blood samples were obtained pre-, immediately post-, and 1 h post-exercise for measurements of malonaldehyde (MDA), superoxide dis-mutase (SOD), interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, SIRT-1, SIRT-2, and SIRT-3. Overall, MDA, SOD, IL-6, SIRT-1, and SIRT-3 levels were significantly increased at post-exercise compared with pre-exercise regardless of exercise intensity ( p p p > 0.05). Altogether, these findings suggest that exercise-induced oxidative stress and inflammatory responses may be dependent on exercise intensity. Moreover, activation of inflammatory cytokines and SIRT family members may be dependent on the intensity of the exercise

Biology · Gene · Inflammation · Oxidative stress · Sirtuin · Sirtuin 1 · Systemic inflammation · Adipose Tissue and Metabolism · Exercise and Physiological Responses · Medicine · Sirtuins and Resveratrol in Medicine · Genetics · Internal Medicine · Physiology

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