Exercise-Induced Circulating Irisin Level Is Correlated with Improved Cardiac Function in Rats
Bibliographic Data
| ID | 15489486 |
|---|---|
| Authors | Dae Yun Seo (0000-0002-4377-5792, Inje University), Jun Hyun Bae (0000-0003-1918-9213, Seoul National University), Tae Nyun Kim (0000-0001-6568-2469, Inje University), Hyo‐Bum Kwak (0000-0003-0451-4554, Inha University), Pham Trong Kha (0000-0002-1689-2897, Inje University), Jin Han (0000-0001-7624-9468, Inje University, corresponding author) |
| Year | 2020 |
| Volume | 17 |
| Issue | 11 |
| Pages | 3863-3863 |
| Publication date | 2020-05-29 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph17113863 |
| PMID | 32485990 |
| OpenAlex | W3031300423 |
| Language | EN |
| Citations received | 2 |
| References cited | 52 |
Irisin, a recently identified myokine, plays an important physiological role in modulating energy homeostasis. However, the role of irisin in cardiac function during exercise has not been evaluated. In this study, we investigated the effect of exercise on irisin, pro-inflammatory cytokines, and cardiac function during 12 weeks of exercise in rats. Eight-week-old Sprague-Dawley male rats were randomly divided into two groups (n = 9 per group): sedentary control (CON) and exercise (EXE) groups. The EXE group was trained on a motorized treadmill at 20 m/min, for 60 min/day, five times/week for 12 weeks. The EXE group showed a decrease in abdominal visceral fat ( p p p p p p p p p < 0.05). In conclusion, exercise decreases the abdominal visceral and epididymal fat and TC levels, possibly caused by elevated irisin levels, thus improving the cardiac function. This suggests that exercise-induced circulating irisin levels correlate with improved cardiac function in rats
Cardiac function curve · Cardiac output · Ejection fraction · Heart failure · Hemodynamics · Myokine · Skeletal muscle · Treadmill · Adipokines, Inflammation, and Metabolic Diseases · Adipose Tissue and Metabolism · Exercise and Physiological Responses · Medicine · Endocrinology · Internal Medicine
| Citations per year | 0.29 |
|---|---|
| Citation span | 2019 - 2021 (3) |
| Highly cited | No |