Dietary Nickel Chloride Induces Oxidative Intestinal Damage in Broilers
Bibliographic Data
| ID | 15499545 |
|---|---|
| Authors | Bangyuan Wu (0000-0002-1310-5309, Sichuan Agricultural University), Hengmin Cui (0000-0003-2963-531X, Sichuan Agricultural University, corresponding author), Xi Peng (0000-0001-8285-2757, Sichuan Agricultural University), Jing Fang (0000-0002-1589-4188, Sichuan Agricultural University), Zhicai Zuo (0000-0002-5547-4436, Sichuan Agricultural University), Junliang Deng (0000-0002-7159-1923, Sichuan Agricultural University), Jianying Huang (0000-0003-0515-9523, Sichuan Agricultural University) |
| Year | 2013 |
| Volume | 10 |
| Issue | 6 |
| Pages | 2109-2119 |
| Publication date | 2013-05-23 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph10062109 |
| PMID | 23702803 |
| PMCID | PMC3717726 |
| OpenAlex | W2033130390 |
| Language | EN |
| Citations received | 1 |
| References cited | 36 |
The purpose of this study was to investigate the oxidative damage induced by dietary nickel chloride (NiCl2) in the intestinal mucosa of different parts of the intestine of broilers, including duodenum, jejunum and ileum. A total of 240 one-day-old broilers were divided into four groups and fed on a corn-soybean basal diet as control diet or the same basal diet supplemented with 300, 600 or 900 mg/kg NiCl2 during a 42-day experimental period. The results showed that the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px), and the ability to inhibit hydroxy radical and glutathione (GSH) content were significantly (p < 0.05 or p < 0.01) decreased in the 300, 600 and 900 mg/kg groups in comparison with those of the control group. In contrast, malondialdehyde (MDA) content was significantly (p < 0.05 or p < 0.01) higher in the 300, 600 and 900 mg/kg groups than that in the control group. It was concluded that dietary NiCl2 in excess of 300 mg/kg could cause oxidative damage in the intestinal mucosa in broilers, which finally impaired the intestinal functions including absorptive function and mucosal immune function. The oxidative damage might be a main mechanism on the effects of NiCl2 on the intestinal health of broilers
Biology · Broiler · Catalase · Duodenum · Enzyme · Glutathione · Glutathione peroxidase · Ileum · Intestinal mucosa · Jejunum · Malondialdehyde · Oxidative stress · Small intestine · Superoxide dismutase · Animal Nutrition and Physiology · Chemistry · Medicine · Moringa oleifera research and applications · Trace Elements in Health · Biochemistry · Endocrinology · Food Science · Internal Medicine
| Citations per year | 0.08 |
|---|---|
| Citation span | 2014 - 2014 (1) |
| Highly cited | No |