Incidence and Survival Trends of Pancreatic Cancer in Girona

Impact of the Change in Patient Care in the Last 25 Years

Bibliographic Data

ID15500112
AuthorsA Garcia (0000-0001-5414-8084, Institut Català d'Oncologia, corresponding author), Lluís Zacarías‐Pons (0000-0001-7968-0819, Generalitat de Catalunya), Helena Teixidor (Generalitat de Catalunya), Marc Nathaniel Valeros (0009-0004-1512-8071, Generalitat de Catalunya), Raquel Liñan (Institut Català d'Oncologia), M Carmen Carmona-García (0000-0002-4011-9474, Institut Català d'Oncologia), Montse Puigdemont (0000-0001-9961-3699, Generalitat de Catalunya), Walter Carbajal (Institut Català d'Oncologia), R Guardeño (Institut Català d'Oncologia), Núria Malats (0000-0003-2538-3784, Spanish National Cancer Research Centre), Eric J Duell (0000-0001-5256-0163, Institut d'Investigació Biomédica de Bellvitge), Rafael Marcos-Gragera (0000-0001-9824-3657, Generalitat de Catalunya)
Year2020
Volume17
Issue24
Pages9538-9538
Publication date2020-12-19
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph17249538
PMID33352812
OpenAlexW3116181341
LanguageEN
Citations received1
References cited1

(1) Background: We investigated the incidence and survival trends for pancreatic cancer (PC) over the last 25 years in the Girona region, Catalonia, Spain; (2) Methods: Data were extracted from the population-based Girona Cancer Registry. Incident PC cases during 1994-2015 were classified using the International Classification of Diseases for Oncology Third Edition (ICD-O-3). Incidence rates age-adjusted to the European standard population (ASR E ) and world standard population (ASR W ) were obtained. Trends were assessed using the estimated annual percentage of change (EAPC) of the ASR E13. Observed and relative survivals (RS) were estimated with the Kaplan-Meier and Pohar Perme methods, respectively; (3) Results: We identified 1602 PC incident cases. According to histology, 44.4% of cases were exocrine PC, 4.1% neuroendocrine, and 51.1% malignant-non-specified. The crude incidence rate (CR) for PC was 11.43 cases-per-100,000 inhabitants/year. A significant increase of incidence with age and over the study period was observed. PC overall 5-year RS was 7.05% (95% confidence interval (CI) 5.63; 8.84). Longer overall survival was observed in patients with neuroendocrine tumours (5-year RS 61.45%; 95% CI 47.47; 79.55). Trends in 5-year RS for the whole cohort rose from 3.27% (95% CI 1.69-6.35) in 1994-1998 to 13.1% (95% CI 9.98; 17.2) in 2010-2015; (4) Conclusions: Incidence rates of PC in Girona have increased in the last two decades. There is a moderate but encouraging increase in survival thorough the study period. These results can be used as baseline for future research

Cancer · Cancer registry · Cohort · Confidence interval · Environmental health · Incidence (geometry · Pancreatic cancer · Population · Relative survival · Cancer Genomics and Diagnostics · Demography · Medicine · Neuroendocrine Tumor Research Advances · Pancreatic and Hepatic Oncology Research · Internal Medicine

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