Multidimensional Frailty Predicts Mortality Better than Physical Frailty in Community-Dwelling Older People

A Five-Year Longitudinal Cohort Study

Bibliographic Data

ID15500170
AuthorsAlberto Cella (0000-0001-6234-6320, Ente Ospedaliero Ospedali Galliera), Nicola Veronese (0000-0002-9328-289X, Ente Ospedaliero Ospedali Galliera, corresponding author), Monica Pomata (Ente Ospedaliero Ospedali Galliera), Katerin Leslie Quispe Guerrero (Ente Ospedaliero Ospedali Galliera), Clarissa Musacchio (Ente Ospedaliero Ospedali Galliera), Barbara Senesi (Ente Ospedaliero Ospedali Galliera), Camilla Prete (Ente Ospedaliero Ospedali Galliera), Erica Tavella (Ente Ospedaliero Ospedali Galliera), Ekaterini Zigoura (0000-0001-5825-8520, Ente Ospedaliero Ospedali Galliera), Giacomo Siri (0000-0001-8006-0668, Ente Ospedaliero Ospedali Galliera), Alberto Pilotto (0000-0002-8615-1955, Ente Ospedaliero Ospedali Galliera)
Year2021
Volume18
Issue23
Pages12435-12435
Publication date2021-11-26
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph182312435
PMID34886161
OpenAlexW3216009588
LanguageEN
Citations received2
References cited27

Frailty is a common syndrome in older people that carries an increased risk of mortality. Two main models describe frailty, either as a loss of physical functions or as an accumulation of multiple deficits. The aim of our study was to compare the physical frailty index developed in the Cardiovascular Health Study (CHS) with a multidimensional frailty tool, the Multidimensional Prognostic Index (MPI), in predicting death in community-dwelling older subjects. Four hundred and seven community-dwelling older subjects were enrolled. Each subject underwent a comprehensive geriatric assessment (CGA) with calculation of the MPI and CHS index. Mortality was recorded over the following 5 years. In the overall sample (mean age of 77.9 ± 4.5 years; 51.6% female), 53 subjects (13%) died during the 5-year follow-up period. Both the MPI and CHS index were able to predict mortality; however, the MPI was significantly more accurate than the CHS index in predicting mortality (C-index = 0.69 and 0.59, respectively; p < 0.001), with a statistically significant difference of 10%. In conclusion, multidimensional frailty, assessed by the MPI, predicts five-year mortality in community-dwelling older people better than physical frailty, as assessed by the CHS index. These findings suggest the usefulness of assessing frailty by means of CGA-based tools to predict relevant health-negative outcomes in older people

Cohort · Cohort study · Frailty Index · Frailty syndrome · Index (typography · Longitudinal study · Older people · Demography · Frailty in Older Adults · Health Systems, Economic Evaluations, Quality of Life · Medicine · Nutrition and Health in Aging · Gerontology · Internal Medicine

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