Hair Cortisol Concentrations as a Biomarker to Predict a Clinical Pregnancy Outcome after an IVF Cycle

A Pilot Feasibility Study

Bibliographic Data

ID15500806
AuthorsDiana C Santa-Cruz (0000-0003-1714-3019, Universidad Rey Juan Carlos, corresponding author), Rafael A Caparros-Gonzalez (0000-0002-0565-1123, Universidad de Granada), Borja Romero-Gonzalez (0000-0002-6350-1836, Universidad de Granada), Maria Isabel Peralta-Ramirez (0000-0001-8201-8906, Universidad de Granada), Raquel Gonzalez-Perez (0000-0002-7956-9763, Universidad de Granada), Juan A García-Velasco (0000-0003-1005-8727, Universidad Rey Juan Carlos)
Year2020
Volume17
Issue9
Pages3020-3020
Publication date2020-04-27
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph17093020
PMID32349221
OpenAlexW3017474059
LanguageEN
Citations received1
References cited44

Our objective was to examine the feasibility of hair cortisol concentrations (HCC) as a biomarker to predict clinical pregnancy outcomes and investigate its potential associations with perceived anxiety, resilience, and depressive symptoms. A total of 43 participants were assessed using HCC, the state trait anxiety inventory (STAI), resilience scale (RS), and the depression subscale of the symptom checklist 90-R (SCL-90-R). Participants were approached at their second consultation with the reproductive endocrinologist (T1), before scheduling their IVF cycle, and then 12 weeks after (T2), at their post-transfer visit with the study coordinators, before the human chorionic gonadotropin (HCG) pregnancy test. The logistic regression model revealed that HCC at T2 predicted 46% of a positive pregnancy test [R2 = 0.46, (ß = 0.11, p p = 0.01) and resilience at T2 (t = -4.89, p = 0.01). HCC might be a promising biomarker to calculate the probability of pregnancy in women using assisted reproductive technologies (ART)

Anxiety · Biology · Biomarker · Depression (economics · Gynecology · Hormone · Human chorionic gonadotropin · Logistic regression · Mood · Obstetrics · Pregnancy · Psychiatry · Clinical Psychology · Medicine · Ovarian function and disorders · Reproductive Health and Technologies · Reproductive System and Pregnancy · Internal Medicine

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