HBM4EU Diisocyanates Study—Research Protocol for a Collaborative European Human Biological Monitoring Study on Occupational Exposure

Bibliographic Data

ID15501037
AuthorsKate Jones (0000-0002-3090-3353, Health & Safety Laboratory, corresponding author), Karen S Galea (0000-0002-9540-8513, Institute of Occupational Medicine), Bernice Scholten (0000-0003-3965-4389, Netherlands Organisation for Applied Scientific Research), Marika Loikala (Finnish Institute of Occupational Health), Simo P Porras (Finnish Institute of Occupational Health), Radia Bousoumah (0000-0001-8751-9961, Institut National de Recherche et de Sécurité), Sophie Ndaw (0000-0002-7518-2465, Institut National de Recherche et de Sécurité), Elizabeth Leese (0000-0002-3607-4592, Health & Safety Laboratory), Henriqueta Louro (0000-0001-9744-7332, National Institute of Health Dr. Ricardo Jorge), Maria João Silva (0000-0003-1017-8315), Susana Viega (0000-0003-1015-8760, Universidade Nova de Lisboa), Lode Godderis (0000-0003-4764-8835, KU Leuven), Jelle Verdonck (0000-0002-4105-5126, KU Leuven), Katrien Poels (0000-0003-4397-6831, KU Leuven), Thomas Göen (0000-0002-8226-9227, Friedrich-Alexander-Universität Erlangen-Nürnberg), Radu Corneliu Duca (0000-0002-9350-3816, Laboratoire National de Santé), Tiina Santonen (0000-0002-8150-4985, Finnish Institute of Occupational Health), HBM4EU Diisocyanates Study Team
Year2022
Volume19
Issue14
Pages8811-8811
Publication date2022-07-20
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph19148811
PMID35886663
OpenAlexW4286005872
LanguageEN
References cited1

Diisocyanates have long been a leading cause of occupational asthma in Europe, and recently, they have been subjected to a restriction under the REACH regulations. As part of the European Human Biomonitoring project (HBM4EU), we present a study protocol designed to assess occupational exposure to diisocyanates in five European countries. The objectives of the study are to assess exposure in a number of sectors that have not been widely reported on in the past (for example, the manufacturing of large vehicles, such as in aerospace; the construction sector, where there are potentially several sources of exposure (e.g., sprayed insulation, floor screeds); the use of MDI-based glues, and the manufacture of spray adhesives or coatings) to test the usability of different biomarkers in the assessment of exposure to diisocyanates and to provide background data for regulatory purposes. The study will collect urine samples (analysed for diisocyanate-derived diamines and acetyl-MDI-lysine), blood samples (analysed for diisocyanate-specific IgE and IgG antibodies, inflammatory markers, and diisocyanate-specific Hb adducts for MDI), and buccal cells (micronucleus analysis) and measure fractional exhaled nitric oxide. In addition, occupational hygiene measurements (air monitoring and skin wipe samples) and questionnaire data will be collected. The protocol is harmonised across the participating countries to enable pooling of data, leading to better and more robust insights and recommendations

Asthma · Biology · Biomonitoring · Buccal swab · Environmental health · Exhaled nitric oxide · Micronucleus test · Occupational asthma · Occupational exposure · Pathology · Protocol (science · Toxicity · Air Quality and Health Impacts · Chemistry · Indoor Air Quality and Microbial Exposure · Medicine · Occupational exposure and asthma · Environmental Chemistry · Immunology

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