Factors Associated with Unfavourable Treatment Outcomes in Patients with Tuberculosis

A 16-Year Cohort Study (2005–2020), Republic of Karakalpakstan, Uzbekistan

Bibliographic Data

ID15501080
AuthorsJamshid Gadoev (0000-0003-3998-5786, Central Bank of Uzbekistan, corresponding author), Damin Asadov (0000-0003-2192-1418, Tashkent Pediatric Medical Institute), Anthony Harries (0000-0001-6113-9741, University of London), Ajay Kumar (0000-0003-1762-6627, Yenepoya University), Ajay M V Kumar (0000-0003-1011-8531, International Union Against Tuberculosis and Lung Disease), Martin J Boeree (0000-0002-7444-921X, Radboud University Nijmegen), Arax Hovhannesyan (0000-0002-7904-9071, World Health Organization Regional Office for Europe), Lianne Kuppens (Central Bank of Uzbekistan), Askar Yedilbayev (0000-0001-8557-5046, World Health Organization Regional Office for Europe), Oleksandr Korotych (World Health Organization Regional Office for Europe), Atadjan Hamraev (Tashkent Pediatric Medical Institute), Kallibek Kudaybergenov (Republican Phthisiology and Pulmonology Center Named after Sultanov, Nukus 1735401, Republic of Karakalpakstan), Barno Abdusamatova (Ministry of Health of the Republic of Uzbekistan), Bakhtinur Khudanov (0000-0003-2080-1975, Ministry of Health of the Republic of Uzbekistan), Masoud Dara (0000-0003-0025-6607, World Health Organization Regional Office for Europe)
Year2021
Volume18
Issue23
Pages12827-12827
Publication date2021-12-05
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph182312827
PMID34886554
OpenAlexW4200440545
LanguageEN
Citations received2
References cited24

Tuberculosis (TB) remains a public health burden in the Republic of Karakalpakstan, Uzbekistan. This region-wide retrospective cohort study reports the treatment outcomes of patients registered in the TB electronic register and treated with first-line drugs in the TB Programme of the Republic of Karakalpakstan from 2005-2020 and factors associated with unfavourable outcomes. Among 35,122 registered patients, 24,394 (69%) patients were adults, 2339 (7%) were children, 18,032 (51%) were male and 19,774 (68%) lived in rural areas. Of these patients, 29,130 (83%) had pulmonary TB and 7497 (>22%) had been previously treated. There were 7440 (21%) patients who had unfavourable treatment outcomes. Factors associated with unfavourable treatment outcomes included: increasing age, living in certain parts of the republic, disability, pensioner status, unemployment, being HIV-positive, having pulmonary TB, and receiving category II treatment. Factors associated with death included: being adult and elderly, living in certain parts of the republic, having a disability, pensioner status, being HIV-positive, and receiving category II treatment. Factors associated with failure included: being adolescent, female, having pulmonary TB. Factors associated with loss to follow-up included: being male, disability, pensioner status, unemployment, receiving category II treatment. In summary, there are sub-groups of patients who need special attention in order to decrease unfavourable treatment outcomes

Cohort · Pathology · Pulmonary tuberculosis · Retrospective cohort study · Tuberculosis · Unemployment · Demography · Medicine · Tuberculosis Research and Epidemiology · Internal Medicine · Pediatrics

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