Hypertensive Disorders during Pregnancy and Anthropometric Measurement of Children up to 7 Years of Age

The Hokkaido Birth Cohort Study in Japan

Bibliographic Data

ID15501592
AuthorsKritika Poudel (0000-0003-4509-5499, Hokkaido University), Sumitaka Kobayashi (0000-0002-0396-8637, Hokkaido University), Chihiro Miyashita (0000-0003-0996-3631, Hokkaido University), Takeshi Yamaguchi (0000-0002-5063-9924, Hokkaido University), Naomi Tamura (0000-0003-2116-4023, Hokkaido University), Atsuko Araki (0000-0002-3065-262X, Hokkaido University), Yu Ait Bamai (0000-0003-2510-4757, Hokkaido University), Sachiko Itoh (Hokkaido University), Keiko Yamazaki (0000-0003-2027-8758, Hokkaido University), Hideyuki Masuda (0000-0002-4924-1804, Hokkaido University), Mariko Itoh (Hokkaido University), Reiko Kishi (0000-0001-8173-9269, Hokkaido University, corresponding author)
Year2021
Volume18
Issue20
Pages10951-10951
Publication date2021-10-18
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph182010951
PMID34682697
OpenAlexW3207513426
LanguageEN
References cited53

Hypertensive disorders during pregnancy (HDP) increase the risk of offspring with a low birth weight, preterm birth and small-for-gestational age; however, evidence of the anthropometric measurements during early childhood remains limited. We aimed to understand the associations between maternal HDP and anthropometric measurements of children aged up to seven years in a Japanese cohort. In total, 20,926 mother-infant pairs participated in the Hokkaido Study on Environment and Children's Health, Japan, from 2002 to 2013. Medical reports were used to confirm HDP exposure, while weight, height, height z score, and weight z score were the outcomes. The prevalence of HDP in the study population was 1.7%. The birth height of male children born to HDP mothers was smaller as compared to those born to non-HDP mothers. When adjusted with covariates, the linear regressions showed significant changes in birth weight (β: -79.3; 95% confidence interval [CI]: -154.8, -3.8), birth height (-0.67; 95% CI: -1.07, -0.26), weight at seven years (1.21; 95% CI: 0.13, 2.29), and weight gain between four and seven years (1.12; 95% CI: 0.28, 1.96) of male children exposed to HDP. Differences were more significant in male children than female. Our study showed that despite low birth weight, male children exposed to HDP caught up with their growth and gained more weight by seven years of age compared with male children not exposed to HDP, whereas no such differences were observed in female children; however, this finding requires replication

Anthropometry · Birth weight · Cohort · Cohort study · Confidence interval · Environmental health · Gestational age · Low birth weight · Obstetrics · Offspring · Population · Pregnancy · Birth, Development, and Health · Demography · Gestational Diabetes Research and Management · Medicine · Pregnancy and preeclampsia studies · Internal Medicine · Pediatrics

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