Association between Serum Vitamin Levels and Depression in U.S. Adults 20 Years or Older Based on National Health and Nutrition Examination Survey 2005–2006
Bibliographic Data
| ID | 15501734 |
|---|---|
| Authors | Xiaomin Huang (0000-0001-8040-511X, Nanjing Medical University), Yun Fan (0000-0003-2197-8043, Nanjing Medical University), Xiumei Han (0009-0003-6244-4838, Nanjing Medical University), Zhenyao Huang (Nanjing Medical University), Mingming Yu (0000-0001-9957-6568, Nanjing Medical University), Yan Zhang (0000-0001-8460-2671, Nanjing Medical University), Qiaoqiao Xu (0000-0001-7315-5431, Nanjing Medical University), Xiuzhu Li (Nanjing Medical University), Xinru Wang (0000-0002-0213-6425, Nanjing Medical University), Chuncheng Lu (0000-0003-3689-9188, Nanjing Medical University, corresponding author), Yankai Xia (0000-0003-0484-4035, Nanjing Medical University, corresponding author) |
| Year | 2018 |
| Volume | 15 |
| Issue | 6 |
| Pages | 1215-1215 |
| Publication date | 2018-06-09 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph15061215 |
| PMID | 29890739 |
| OpenAlex | W2807284482 |
| Language | EN |
| Citations received | 2 |
| References cited | 41 |
Depression is one of the leading causes of disability around the world. Although several studies have been conducted to analyze the association between vitamins and depression, the results have been inconsistent. Based on the database of National Health and Nutrition Examination Survey (NHANES) (2005−2006), a cross-sectional analysis was conducted to uncover the correlations between serum vitamin concentrations and depression in 2791 participants over 20 years of age. Vitamin concentrations in serum were measured by high performance liquid chromatography (HPLC), a standardized liquid chromatography-tandem mass spectrometry (LC-MS/MS) or radioassay kit method. A nine-item Patient Health Questionnaire (PHQ-9) was used to assess depression symptoms. The binary logistic regression model was applied to analyze the association between vitamins and depression. In the whole population, negative associations were discovered between folate concentrations ( p for trend = 0.02), trans -β-carotene ( p for trend = 0.01) and depression, while positive associations were found among vitamin B12 concentrations ( p for trend = 0.008), vitamin A concentrations ( p for trend = 0.01) and depression. In order to evaluate the influence of gender on the pathogenesis of depression of vitamins exposure, we performed gender-stratified analysis. In females, folate concentrations ( p for trend = 0.03) and vitamin B12 concentrations ( p for trend = 0.02) were correlated with depression. In males, no significant association was found between depression and serum vitamin concentrations. The correlation of vitamins with depression deserves further investigation in larger and diverse populations, especially in females
Anxiety · Cross-sectional study · Depression (economics · Depressive symptoms · Environmental health · Logistic regression · National Health and Nutrition Examination Survey · Pathology · Patient Health Questionnaire · Population · Psychiatry · Vitamin · Vitamin B12 · Vitamin D and neurology · Alcoholism and Thiamine Deficiency · Folate and B Vitamins Research · Medicine · Nutritional Studies and Diet · Internal Medicine · Physiology
| Unique citing works | 2 |
|---|---|
| Citations per year | 0,5 |
| Citation span | 2022 - 2023 (2) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 2 |