Low Dose Cadmium Inhibits Proliferation of Human Renal Mesangial Cells via Activation of the JNK Pathway
Bibliographic Data
| ID | 15501882 |
|---|---|
| Authors | Xiaocui Chen (0009-0002-4927-390X, Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, 16766 Jingshi Road, Jinan 250014, China), Jiayao Chen (0000-0001-6749-8358, Shandong University), Jing Li (0000-0001-7792-4322, Shandong Normal University), Zuowang Cheng (Taishan Medical University), Yinghua Xu (0000-0003-0148-0184, Taishan Medical University), Xia Wang (0000-0002-5256-0611, Shandong University), Xiaorui Li (0000-0002-0627-3101, Taishan Medical University), Dongmei Xu (0000-0002-8192-1535, Shandong University), Carolyn Kapron (0000-0001-8630-8214, Trent University), Ju Liu (0000-0002-1352-1986, Shandong University, corresponding author) |
| Year | 2016 |
| Volume | 13 |
| Issue | 10 |
| Pages | 990-990 |
| Publication date | 2016-10-07 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph13100990 |
| PMID | 27739415 |
| OpenAlex | W2528104714 |
| Language | EN |
| References cited | 52 |
Cadmium (Cd) is a heavy metal and environmental pollutant. The kidney is the principal target organ of Cd exposure. Previously, we found that low concentration of Cd damages the integrity of the glomerular filtration barrier. However, little is known about the effects of Cd on renal mesangial cells, which provide structural support for the glomerular capillary loops and regulate intraglomerular blood flow. In this study, human renal mesangial cells (HRMCs) were cultured in the presence of serum and treated with 4 μM Cd. We found that Cd activates the c-Jun N-terminal kinase (JNK) pathway, and increases the protein levels of c-Jun and c-Fos. Cd treatment also induces a decrease in proliferation and an increase in apoptosis of HRMCs, but only the decrease in HRMC proliferation was reversed by pretreatment with SP600125, an inhibitor of the JNK pathway. In addition, Cd does not change the expression of α-smooth muscle actin and platelet-derived growth factor receptor-β, the markers of mesangial cells, or the alignment of the filamentous actin (F-actin) cytoskeleton of HRMCs. Our data indicate that the JNK pathway mediates the inhibitory effects of Cd on HRMC proliferation
Actin · Actin cytoskeleton · Apoptosis · Biology · c-jun · Cell · Cell growth · Cytoskeleton · Kidney · Mesangial cell · Signal transduction · Transcription factor · Chemistry · Heavy Metal Exposure and Toxicity · Medicine · Mercury impact and mitigation studies · Biochemistry · Cell Biology · Endocrinology · Internal Medicine
| Citation velocity | historical |
|---|---|
| Highly cited | No |