Exposure to Particulate PAHs on Potential Genotoxicity and Cancer Risk among School Children Living Near the Petrochemical Industry
Bibliographic Data
| ID | 15503828 |
|---|---|
| Authors | Nor Ashikin Sopian (0000-0003-3903-7479, Universiti Putra Malaysia), Juliana Jalaludin (0000-0002-7910-6945, Universiti Putra Malaysia, corresponding author), Suhaili Abubakar (0000-0002-2217-4509, Universiti Putra Malaysia), Suhaili Abu Bakar (Universiti Putra Malaysia), Titi Rahmawati Hamedon (0000-0002-2245-8659, Universiti Putra Malaysia), Mohd Talib Latif (0000-0003-2339-3321, National University of Malaysia) |
| Year | 2021 |
| Volume | 18 |
| Issue | 5 |
| Pages | 2575-2575 |
| Publication date | 2021-03-04 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph18052575 |
| PMID | 33806616 |
| OpenAlex | W3135325204 |
| Language | EN |
| Citations received | 2 |
| References cited | 96 |
This study aimed to assess the association of exposure to particle-bound (PM 2.5 ) polycyclic aromatic hydrocarbons (PAHs) with potential genotoxicity and cancer risk among children living near the petrochemical industry and comparative populations in Malaysia. PM 2.5 samples were collected using a low-volume sampler for 24 h at three primary schools located within 5 km of the industrial area and three comparative schools more than 20 km away from any industrial activity. A gas chromatography-mass spectrometer was used to determine the analysis of 16 United States Environmental Protection Agency (USEPA) priority PAHs. A total of 205 children were randomly selected to assess the DNA damage in buccal cells, employing the comet assay. Total PAHs measured in exposed and comparative schools varied, respectively, from 61.60 to 64.64 ng m -3 and from 5.93 to 35.06 ng m -3 . The PAH emission in exposed schools was contributed mainly by traffic and industrial emissions, dependent on the source apportionment. The 95th percentiles of the incremental lifetime cancer risk estimated using Monte Carlo simulation revealed that the inhalation risk for the exposed children and comparative populations was 2.22 × 10 -6 and 2.95 × 10 -7 , respectively. The degree of DNA injury was substantially more severe among the exposed children relative to the comparative community. This study reveals that higher exposure to PAHs increases the risk of genotoxic effects and cancer among children
Beijing · Biology · Comet Assay · DNA damage · Environmental health · Genotoxicity · Geography · Toxicity · Air Quality and Health Impacts · Carcinogens and Genotoxicity Assessment · Chemistry · Environmental Science · Medicine · Toxic Organic Pollutants Impact · Environmental Chemistry · Toxicology
| Unique citing works | 2 |
|---|---|
| Citations per year | 0.4 |
| Citation span | 2021 - 2025 (5) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 2 |