Alterations in Circulating MicroRNAs and the Relation of MicroRNAs to Maximal Oxygen Consumption and Intima–Media Thickness in Ultra-Marathon Runners

Bibliographic Data

ID15503912
AuthorsCeren Eyileten (0000-0002-3324-9625, Medical University of Warsaw), Alex Fitas (0000-0003-2879-5979, Medical University of Warsaw), Daniel Jakubik (0000-0003-1388-1436, Medical University of Warsaw), Pamela Czajka (0000-0002-0193-0192, Medical University of Warsaw), Anna Mróz (0000-0001-7169-5493, Józef Piłsudski University of Physical Education in Warsaw), Anna Czajkowska (0000-0002-2128-0131, Józef Piłsudski University of Physical Education in Warsaw), Katarzyna Witek (0000-0002-1130-6756, Józef Piłsudski University of Physical Education in Warsaw), Wawrzyniec Bakalarski (Józef Piłsudski University of Physical Education in Warsaw), Salvatore De Rosa (0000-0001-5388-942X, Magna Graecia University), Marek Postuła (0000-0002-7826-4458, Medical University of Warsaw, corresponding author), Łukasz A Małek (0000-0002-9586-0163, Institute of Cardiology)
Year2021
Volume18
Issue14
Pages7234-7234
Publication date2021-07-06
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph18147234
PMID34299680
OpenAlexW3182590825
LanguageEN
References cited65

The impact of long-term training on cardiovascular disease (CVD) is not clear. Carotid intima-media thickness (CIMT) test is recommended as a useful measure to diagnose the early stages of atherosclerosis. MicroRNAs (miRNAs) are altered due to endurance exercise and can be promising biomarkers of pathophysiological changes. We aimed to evaluate the association of circulating miRNAs with physical fitness and markers of atherosclerosis in ultra-marathon runners. Ultra-marathon runners had 28-fold upregulation of miR-125a-5p expressions compared to control individuals ( p = 0.002), whereas let-7e and miR-126 did not differ statistically between ultra-marathon runners and controls. In the ultra-marathon runners' group, negative correlations were observed between VO 2 max/kg and relative expression of miR-125a-5p and miR-126 (r = -0.402, p = 0.028; r = -0.438, p = 0.032, respectively). Positive correlations were observed between CIMT and miR-125a-5p and miR-126 (r = 0.388, p = 0.050; r = 0.504, p = 0.023, respectively) in ultra-marathon runners. Individuals with the highest quartile of VO 2 max/kg had 23-fold lower miR-126 expression in comparison to subgroups with lower VO 2 max/kg ( p = 0.017). Our results may indicate that both miRNAs may serve as a biomarker for early pathological changes leading to atherosclerosis burden in athletes. Furthermore, the association between miRNAs and traditional risk factors for CVD indicate a possible use of these molecules as early biomarkers of future cardiovascular health

Athletes · Biology · Biomarker · Blood pressure · Cardiology · Carotid arteries · Gene · Intima-media thickness · Long distance runners · microRNA · Pathological · Physical therapy · Quartile · VO2 max · Cardiovascular Disease and Adiposity · Cardiovascular Effects of Exercise · Medicine · MicroRNA in disease regulation · Genetics · Internal Medicine

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